The station was named after the eponymous square it lies under, which was named after George of Poděbrady. Opened in 1980, the Jiřího z Poděbrad is an underground trispan station. The main materials used on walls and ceilings are anodized aluminium, marble and granite. The only exit leads to an underground vestibule, which is connected with the platform by escalator tunnel.
At the beginning of the Radiohead song "A Reminder," the female voice of the Metro's automated announcement system can be heard announcing this station. It is also used in the song "Mind the Gap" by Calexico.