Joffroy's sign

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Joffroy's sign is a clinical sign in which there is a lack of wrinkling of the forehead when a patient looks up with the head bent forwards.[1] It occurs in patients with exophthalmos in Graves disease.[2]

The sign is named after Alexis Joffroy.


  1. ^ Woods, Alan (May 1946). "The Ocular Changes of Primary Diffuse Toxic Goitre A Review". Medicine. 25 (2): 113–154. doi:10.1097/00005792-194605000-00002. 
  2. ^ Means, JH (January 1944). "The Nature of Graves' Disease With Special Reference to Its Ophthalmic Component". American Journal of the Medical Sciences. 207 (1): 1–18. doi:10.1097/00000441-194401000-00001. 

External links[edit]

Joffroy's sign I at Who Named It?