|Sir John Gaddum
|Born||John Henry Gaddum
31 March 1900
|Died||30 June 1965
University College London
|Alma mater||Rugby School
Trinity College, Cambridge
|Known for||first scientist to postulate that 5-HT might have a role in mood regulation|
|Notable awards||Fellow of the Royal Society|
Early life and education
From 1927-33, Gaddum worked under Henry Dale at the National Institute for Medical Research, and helped develop the classical laws of drug antagonism. He showed that sympathetic nerves release adrenaline. Together with Ulf von Euler, he established the release of acetylcholine in autonomic ganglia.
From 1933-35, Gaddum was professor of pharmacology at the University of Cairo. Subsequent to this he took up a chair at University College London, from 1935–38 and University of London from 1938-42.
In experiments with lysergic acid diethylamide (LSD), Gaddum explained how it causes mental disturbances by blocking the stimulating effects of serotonin. He was the first scientist to postulate that 5-HT might have a role in mood regulation.
Gaddum authored an advanced pharmacology text, "Gaddum's Pharmacology", which was considered definitive for decades.
Gaddum served in the British Army from 1940–42, rising to Lieutenant Colonel.
In 1929, Gaddum married Iris Mary Harmer.
- Feldberg, W. (1967). "John Henry Gaddum 1900-1965". Biographical Memoirs of Fellows of the Royal Society 13: 56–26. doi:10.1098/rsbm.1967.0003.
- "John H. Gaddum". NNDB. Retrieved 2013-08-25.
- The London Gazette: . 31 December 1963.
- The London Gazette: . 18 February 1964.
- Gaddum, J. H. (1957), SEROTONIN-LSD INTERACTIONS. Annals of the New York Academy of Sciences, 66: 643–648.
- "Royal Society: Gaddum, Sir John Henry (1900-1965)". AIM25. Retrieved 2006-05-19.
- "Gaddum Papers". The Royal Society. Retrieved 2007-03-01.