John James Pringle

John James Pringle

A man with adenoma sebaceum, 1903.

John James Pringle (1855 – 18 December 1922) was a Scottish dermatologist. He was born in Borgue, Kirkcudbrightshire and educated at Merchiston Castle school. He graduated in medicine from Edinburgh University in 1876. He then travelled abroad, studying in Dublin, Vienna, Paris and Berlin, studying dermatology in Vienna under Ferdinand von Hebra and Moriz Kaposi, and in Paris under Jean Baptiste Emile Vidal and Jean Alfred Fournier.

He settled in London in 1882. From 1888 to 1920, we worked as a dermatologist at the Middlesex Hospital in London. He caught tuberculosis and spent six months of 1903 in a sanatorium. He never fully recovered and, whilst on a trip intended to improve his health, he died at Christchurch, New Zealand. He is related to Sir John Pringle.

Adenoma sebaceum

JJ Pringle is primarily remembered for the eponym: Pringle's Adenoma Sebaceum. Now known as facial angiofibroma, this papular facial rash, of distinctive butterfly distribution, was first described in English by Pringle. In 1890 he reported in detail the case of a 25-year-old woman, who was not "particularly bright intellectually" and had presented with both skin and digestive complaints. He described the papules in detail, noting the capillary involvement and their fibrous nature. He believed that the sebaceous glands were the source of the problem. Pringle was unfamiliar with the condition so presented his patient to a meeting of the Dermatological Society in 1889-01-09. Two visitors recognised a similarity with models in the Museum of the Saint Louis Hospital in Paris. This led Pringle to become acquainted with five other cases, two previously published, that he includes in his report.

Pringle adopted the term "adenoma sebaceum" from Félix Balzer's phrase "adénomes sébacés". The papules were in fact neither adenoma nor derived from sebaceous glands. Pringle dismisses one report of a hereditary aspect as "dubious". The patients are generally reluctant to submit to treatment, which leads to considerable bleeding and pain.

Several years later, physicians would rcognise that the combination of adenoma sebaceum, epilepsy and learning disability was diagnostic for tuberous sclerosis. The three signs are known as Vogt's triad. Although Pringle's report does not mention epilepsy, most of the patients are of limited intelligence, and these cases are regarded as early accounts of tuberous sclerosis.

Achievements

• 1891–1895, editor of the British Journal of Dermatology.
• 1895–1901, secretary of the Dermatological Society.
• 1896, appointed Secretary General to the International Congress of Dermatology.
• President of the dermatology section of the Royal Society of Medicine

Publications

• Pringle, JJ (1890). "A case of congenital adenoma sebaceum". British Journal of Dermatology, Oxford. 2: 1–14.
• Pringle, JJ (1891). "Angiokeratoma". British Journal of Dermatology, Oxford. 3: 237–244, 282–285, 309–317.

See also

• Timeline of tuberous sclerosis

References

• Enersen, Ole Daniel. "John James Pringle". Who Named It?. Retrieved 19 January 2007.
• Jansen FE, van Nieuwenhuizen O, van Huffelen AC (2004). "Tuberous sclerosis complex and its founders". Journal of Neurology Neurosurgery and Psychiatry. 75 (5): 770. doi:10.1136/jnnp.2003.027524. PMC 1763558. PMID 15090576.
• Gold, Stephen. "A Glimmering of Light". A Biographical History of British Dermatology. British Association of Dermatologists. Retrieved 2 February 2007.

Further reading

• Lyell Alan (1985). "The man behind the eponym. John James Pringle (1855-1922)". The American Journal of Dermatopathology. 7 (5): 441–5. doi:10.1097/00000372-198510000-00008. PMID 3911795.