Quayle operated a retail butcher business, and later became involved in the construction industry.
In 1914 Quayle was appointed Deputy Collector of Internal Revenue for New York's first district, and he served until 1919.
From 1919 to 1923 Quayle was Brooklyn's Deputy Borough Clerk. In 1920, Quayle served as an Alternate Delegate to the Democratic National Convention.
In 1922 Quayle was the successful Democratic nominee for a seat in Congress. He was reelected four times and served from March 4, 1923 until his death. Because of his death after the 1930 elections and before the start of the 72nd Congress in 1931, Quayle did not serve the final term to which he had been elected. The February 1931 special election to succeed him was won by Matthew Vincent O'Malley, but O'Malley died in May before being sworn in. The seat remained vacant until John J. Delaney was elected in November 1931.
- United States Congress. "John Quayle (id: Q000008)". Biographical Directory of the United States Congress. Retrieved on 2013-10-09
- John Quayle at Find a Grave
- New York Times, Quayle Designated for Congress in 7th; Choice of Deputy City Clerk Ends Deadlock Over Delaney, Elder and McArdle, August 16, 1922
- New York Times, John F. Quayle Dies; Congress Member; Democrat Who Represented Seventh District, Brooklyn, a Pneumonia Victim, November 28, 1930
|U.S. House of Representatives|
Michael J. Hogan
|Member of the U.S. House of Representatives
from New York's 7th congressional district
John J. Delaney