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KIAA1967

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Template:Distinguish2 Template:PBB KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.[1][2][3]

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.[4][5] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.[6]

References

  1. ^ "Entrez Gene: KIAA1967 KIAA1967".
  2. ^ Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647–52. doi:10.1073/pnas.212516099. PMC 129730. PMID 12370419.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature. 451 (7178): 583–6. doi:10.1038/nature06500. PMID 18235501.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1". Nature. 451 (7178): 587–90. doi:10.1038/nature06515. PMC 2866287. PMID 18235502.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites". Cell Cycle. 7 (10): 1467–72. doi:10.4161/cc.7.10.5883. PMC 2423810. PMID 18418069.

Further reading

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