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KSIX may refer to:
- KSIX (AM), a radio station (1230 AM) licensed to serve Corpus Christi, Texas, United States
- KSIX-TV, a television station (channel 25/PSIP 6) licensed to serve Kailua-Kona, Hawaii, United States
- KZTV, a television station (channel 10) licensed to serve Corpus Christi, Texas, United States, which held the call sign KSIX-TV from 1956 to 1957
- K-Six Television, former owner of the Corpus Christi stations
| disambiguation page lists articles associated with the title KSIX.
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