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Karyorrhexis (from Greek κάρυον karyon, "kernel, seed or nucleus", and ῥῆξις rhexis, "bursting") is the destructive fragmentation of the nucleus of a dying cell[1] whereby its chromatin is distributed irregularly throughout the cytoplasm.[2] It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis.

In apoptosis, the cleavage of DNA is done by Ca2+ and Mg2+ -dependent endonucleases.

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  1. ^ Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. Bibcode:1999Natur.401..127Z. doi:10.1038/43591. PMID 10490018. S2CID 36673000.
  2. ^ Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. Retrieved 11 November 2017.