Kurnakov test

From Wikipedia, the free encyclopedia
Jump to: navigation, search

The Kurnakov test, also known as Kurnakov's reaction, is a chemical test devised by Soviet chemist Nikolai Semenovich Kurnakov.[1] [2] [3] It utilizes the phenomenon of the trans effect to distinguish the pairs of cis- and trans-isomers of square complexes of [PtA2X2] (A=NH3, X=halogen or acid radical) type by treating them with thiourea. It is commonly used in platinum mining.

Uses[edit]

Kurnakov test is used to distinguish between cisplatin and transplatin. In hot aqueous solution, the cis compound reacts with aqueous thiourea to give a deeper yellow solution from which yellow needles of tetrakis (thiourea) platinum(II) chloride deposit on cooling, while the trans compound gives a colourless solution from which snow white needles of trans-bis(thiourea)diaammineplatinum(II) deposit on cooling. [4] [5]

References[edit]

  1. ^ The Life and Work of Nikolai Semenovich Kurnakov
  2. ^ Kurnakow, N. (1894). "Ueber complexe Metallbasen; Erste Abhandlung". Journal für Praktische Chemie. 50: 481–507. doi:10.1002/prac.18940500144. 
  3. ^ Kauffman, George B. (1983). "Nikolaĭ Semenovich Kurnakov, the reaction (1893) and the man (1860–1941) a ninety-year retrospective view". Polyhedron. 2 (9): 855–863. doi:10.1016/S0277-5387(00)81400-X. 
  4. ^ Kong, Pi-Chang; Rochon, F.D. (1979). "cis- and trans-Platinum compounds of substituted pyrimidines and their products from thiourea in Kurnakov's reaction". Canadian Journal of Chemistry. 57 (5): 526–529. doi:10.1139/v79-086. 
  5. ^ Woollins, J (1983). "The detection of trace amounts of trans-Pt(NH3)2Cl2 in the presence of cis-Pt(NH3)2Cl2. A high performance liquid chromatographic application of kurnakow's test". Polyhedron. 2 (3): 175–178. doi:10.1016/S0277-5387(00)83954-6.