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Lactivicin is a non beta-lactam antibiotic that is active against a range of Gram-positive and Gram-negative bacteria.[1] Lactivicin demonstrates a similar affinity for penicillin-binding proteins to beta-lactam antibiotics and is also susceptible to beta-lactamase enzymes.[2] The structure of lactivicin is [4S1-2-(4- acetylamino-3-oxo-2-isoxazolidinyl)-5-oxo-tetrahydrofuran-2-carboxylic acid.[2]


  1. ^ Nozaki Y, Katayama N, Harada S, Ono H, Okazaki H (1989). "Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action". J. Antibiot. 42 (10): 84–93. doi:10.7164/antibiotics.42.84. PMID 2493440.
  2. ^ a b Harada S, Tsubotani S, Hida T, Ono H, Okazaki H (1986). "Structure of lactivicin, an antibiotic having a new nucleus and similar biological activities to β-lactam antibiotics". Tetrahedron Letters. 27 (51): 6229–6232. doi:10.1016/S0040-4039(00)85439-8.