Lefferts may refer to:
- Charles M. Lefferts (1873–1923), American illustrator and soldier
- Craig Lefferts (b. 1957), American professional baseball player
- George Lefferts, American writer, producer and director
- John Lefferts (1785–1829), American politician
- Winifred E. Lefferts (1903–1995), American painter, designer and philanthropist
- Lefferts Historic House, Brooklyn, New York
- Ozone Park–Lefferts Boulevard (IND Fulton Street Line), elevated station
- Prospect Lefferts Gardens, Brooklyn, neighborhood
|This disambiguation page lists articles associated with the title Lefferts.
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