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Lefko (Greek: Λευκό, meaning "white") may refer to the following:
- Lefko, Aetolia-Acarnania, a village in the municipality Thermo, Aetolia-Acarnania, Greece
- Popular Unions of Bipartisan Social Groups, a Greek political party, better known by its acronym LEFKO
- Lefko (grape), a synonym for several Greek wine grapes, most notably Aidini
disambiguation page lists articles about distinct geographical locations with the same name.
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