Leopoldo de Gregorio, 1st Marquess of Esquilache

Giuseppe Bonito: Portrait of Leopoldo de Gregorio, marquis of Squillace, Madrid, Museo del Prado.

Leopoldo de Gregorio, Marquis of Squillace (Messina, December 23, 1699 - Venice, September 15, 1785), known in Italian as Marchese di Squillace and in Spanish as Marqués de Esquilache, was an Italian statesman who acted as minister of Charles III of Spain.

Born in Messina, de Gregorio was one of Enlightenment Spain's leading statesmen from the arrival of Charles III to the Marquis's death in 1785. His ability as a military supplier for the Neapolitan army impressed the king and raised him to royal prominence. He was created "Marquis of Squillace" in 1755.

Charles III had been introduced to reform by his mentor in Sicily, Bernardo Tanucci. Although Tanucci remained behind in the Two Sicilies to advice Charles's son, King Ferdinand I of the Two Sicilies, as the two thrones could not be united by consequence of treaty, Charles carried with him a cadre of Italian reformers who saw potential in the Spanish bureaucracy for modernization. De Gregorio was one of them, and was the architect of the first phase of Charles' reforms.

His attempt to modernize the apparel of the average Spaniard resulted in the Esquilache Riots and in his dismissal. Charles was forced to make Squillace ambassador to Venice. It was a move that both Charles and Squillace lamented. Squillace felt that his measures in Spain had deserved a statue, and would comment that he had cleaned and paved the city streets and had created boulevards, and had nevertheless been dismissed.

He died in Venice.