Born Leora Theresa Spellmeyer in Bonne Terre, Missouri, she began singing on stage as a child, and as a young lady began working in vaudeville where she met and married fellow performer Charles Middleton. They then teamed up to create a vaudeville act billed as "Middleton and Spellmeyer."
Using the stage name Laura Spellman, she worked primarily in live theatre, as did her husband, but in 1920 they made their silent film debut together in "Wits vs. Wits." However, she continued working on stage, and appeared in only two more films. Her husband eventually built a very successful career as a character actor in film, notably as "Emperor Ming" in the Flash Gordonserials.
Although sixteen years his junior, Leora Spellman predeceased her husband by four years, dying in 1945 in Los Angeles, California. She is interred in the Hollywood Forever Cemetery in Hollywood next to her husband. Although most published sources list the year of her birth as 1890, her gravestone indicates she was born in 1888.