He was a pupil of the painter Vincenzo di Stefano, although he was strongly influenced by Andrea Mantegna and Jacopo Bellini. He was featured in the Vite of Giorgio Vasari. In Verona, he painted an Adoration of the Magi in the Duomo, and another for the chapel in the bishopric. For the church of San Bernardino, he painted in the chapel of the company of the Maddalena. He also painted a Birth and Assumption of the Virgin. At the Brera Gallery, there is a St. Stephen. There are illuminated books by him in cathedral of Chiusi. The St Sebastian in the Princeton University Art Museum is attributed to Liberale.
He traveled to Siena to work in the Abbey of the monks of the Abbey of Monte Oliveto, where he illuminated a number of manuscripts.