Lineage selection

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Lineage selection, occurs when the frequency of one biological lineage changes in frequency relative to another lineage. Lineage selection is a generalization of individual based natural selection; the stating that an allele is favored by natural selection is equivalent to stating that the lineage bearing the allele is favored by natural selection.[1] For alleles with simple positive or negative fitness effects, lineage and individual based selection are equivalent. However, lineage selection can accommodate a wider array of evolutionary phenomena, such as the adaptive evolution of evolvability,[2] altruism,[1] and recombination.[3] Additionally, lineage selection is useful in determining the effects of mutations in highly structured environments such as tumors.[4]


  1. ^ a b Akçay, Erol; Cleve, Jeremy Van (2016-02-05). "There is no fitness but fitness, and the lineage is its bearer". Phil. Trans. R. Soc. B. 371 (1687): 20150085. doi:10.1098/rstb.2015.0085. ISSN 0962-8436. PMC 4760187. PMID 26729925.
  2. ^ Kirschner, Marc; Gerhart, John (1998-07-21). "Evolvability". Proceedings of the National Academy of Sciences. 95 (15): 8420–8427. doi:10.1073/pnas.95.15.8420. ISSN 0027-8424. PMC 33871. PMID 9671692.
  3. ^ "Lineage Selection and the Maintenance of Sex" (PDF). PLoS ONE. 8 (6e66906): e66906. doi:10.1371/journal.pone.0066906.
  4. ^ Nunney, Leonard (1999-03-07). "Lineage selection and the evolution of multistage carcinogenesis". Proceedings of the Royal Society of London B: Biological Sciences. 266 (1418): 493–498. doi:10.1098/rspb.1999.0664. ISSN 0962-8452. PMC 1689794. PMID 10189713.