Lipid-laden alveolar macrophage

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Lipid-laden alveolar macrophages, also known as pulmonary foam cells,[1] are cells found in bronchoalveolar lavage (BAL) specimens that consist of macrophages containing deposits of lipids (fats).[2] The lipid content of the macrophages can be demonstrated using Oil Red O and other lipophilic stains.[1][3] Increased levels of lipid-laden alveolar macrophages are associated with various respiratory conditions, including chronic smoking,[2] gastroesophageal reflux, lipoid pneumonia, fat embolism,[4] pulmonary alveolar proteinosis[2][5] and pulmonary aspiration.[1][6] Lipid-laden alveolar macrophages have been reported in cases of lung injury associated with vaping.[7][8]

The lipid-laden macrophage index (LLMI) can be calculated by counting 100 macrophages in a BAL specimen treated with a lipid stain and scoring each macrophage from 0 to 4 based on the amount of lipids present in the cell.[4][9] A LLMI score greater than 100 is considered positive for pulmonary aspiration. However, the test is limited by poor reproducibility[4] and low specificity for pulmonary aspiration, as lipid-laden macrophages occur in many respiratory conditions.[6]

See also[edit]

References[edit]

  1. ^ a b c Gibeon, D.; Zhu, J.; Sogbesan, A.; Banya, W.; Rossios, C.; Saito, J.; Rocha, J.P.; Hull, J.H.; Menzies-Gow, A.N.; Bhavsar, P.K.; Chung, K.F. (2014). "Lipid-laden bronchoalveolar macrophages in asthma and chronic cough". Respiratory Medicine. 108 (1): 71–77. doi:10.1016/j.rmed.2013.10.005. ISSN 0954-6111. PMID 24172051.
  2. ^ a b c Fessler, Michael B. (2017). "A New Frontier in Immunometabolism. Cholesterol in Lung Health and Disease". Annals of the American Thoracic Society. 14 (Supplement_5): S399–S405. doi:10.1513/AnnalsATS.201702-136AW. ISSN 2329-6933.
  3. ^ Augustine S. Lee; James P. Utz. "American Thoracic Society - Bronchoalveolar Lavage". American Thoracic Society. Retrieved 8 September 2019.
  4. ^ a b c K.N. Priftis; M.B. Anthracopoulos; E. Eber; A.C. Koumbourlis; R.E. Wood (6 May 2010). "Bronchoalveolar lavage - indications and application". Paediatric Bronchoscopy. Karger Medical and Scientific Publishers. p. 38. ISBN 978-3-8055-9311-3.
  5. ^ Thomassen, Mary Jane; Barna, Barbara P.; Malur, Achut G.; Bonfield, Tracey L.; Farver, Carol F.; Malur, Anagha; Dalrymple, Heidi; Kavuru, Mani S.; Febbraio, Maria (2007). "ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis". Journal of Lipid Research. 48 (12): 2762–2768. doi:10.1194/jlr.P700022-JLR200. ISSN 0022-2275. PMID 17848583.
  6. ^ a b Lahiri, Thomas (2014). "The utility of the lipid-laden macrophage index for the evaluation of aspiration in children". Cancer Cytopathology. 122 (3): 161–162. doi:10.1002/cncy.21365. ISSN 1934-662X. PMID 24302605.
  7. ^ Maddock, Sean D.; Cirulis, Meghan M.; Callahan, Sean J.; Keenan, Lynn M.; Pirozzi, Cheryl S.; Raman, Sanjeev M.; Aberegg, Scott K. (2019). "Pulmonary Lipid-Laden Macrophages and Vaping". New England Journal of Medicine. doi:10.1056/NEJMc1912038. ISSN 0028-4793. PMID 31491073.
  8. ^ Davidson, Kevin; Brancato, Alison; Heetderks, Peter; Mansour, Wissam; Matheis, Edward; Nario, Myra; Rajagopalan, Shrinivas; Underhill, Bailey; Wininger, Jeremy; Fox, Daniel (2019). "Outbreak of Electronic-Cigarette–Associated Acute Lipoid Pneumonia — North Carolina, July–August 2019". MMWR. Morbidity and Mortality Weekly Report. 68 (36). doi:10.15585/mmwr.mm6836e1. ISSN 0149-2195.
  9. ^ Yvan Vandenplas (2017). "Gastroesophageal reflux and cystic fibrosis". Gastroesophageal Reflux in Children: GER in Children. Springer. p. 216. ISBN 978-3-319-60678-1.