View source for List of benzodiazepines

{{Short description|none}}
{{Benzos}}
The tables below contain a '''sample list of benzodiazepines''' and benzodiazepine [[Analog (chemistry)|analogs]] that are commonly prescribed, with their basic [[pharmacological]] characteristics, such as half-life and equivalent doses to other [[benzodiazepines]], also listed, along with their trade names and primary uses. The [[elimination half-life]] is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such as [[anxiolytic]], [[sedative]], [[hypnotic]], [[skeletal muscle relaxant]], [[amnesic]], and [[anticonvulsant]] effects. Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce [[active metabolites]]. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last. Long-acting benzodiazepines with long-acting active metabolites, such as [[diazepam]] and [[chlordiazepoxide]], are often prescribed for benzodiazepine or [[alcohol withdrawal]] as well as for [[anxiety]] if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for [[insomnia]] due to their lesser hangover effect.<ref>{{cite journal | vauthors = Golombok S, Lader M | title = The psychopharmacological effects of premazepam, diazepam and placebo in healthy human subjects | journal = British Journal of Clinical Pharmacology | volume = 18 | issue = 2 | pages = 127–133 | date = August 1984 | pmid = 6148956 | pmc = 1463527 | doi = 10.1111/j.1365-2125.1984.tb02444.x }}</ref><ref>{{cite journal | vauthors = de Visser SJ, van der Post JP, de Waal PP, Cornet F, Cohen AF, van Gerven JM | title = Biomarkers for the effects of benzodiazepines in healthy volunteers | journal = British Journal of Clinical Pharmacology | volume = 55 | issue = 1 | pages = 39–50 | date = January 2003 | pmid = 12534639 | pmc = 1884188 | doi = 10.1046/j.1365-2125.2002.t01-10-01714.x }}{{cbignore|bot=medic}}</ref><ref>{{cite web|url=http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html |title=Benzodiazepine Names |access-date=2009-04-05 |publisher=non-benzodiazepines.org.uk |url-status=dead |archive-url=https://web.archive.org/web/20081208054743/http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html |archive-date=2008-12-08 }}</ref><ref name="Ashton 2007">{{cite web | vauthors = Ashton CH | title = Benzodiazepine Equivalence Table | url = http://www.benzo.org.uk/bzequiv.htm | publisher = benzo.org.uk |date=March 2007 | access-date = 2009-04-05}}</ref><ref>{{cite web | vauthors = Hsiung R | title = Benzodiazepine Equivalence Charts | url = http://www.dr-bob.org/tips/bzd.html | publisher = dr-bob.org | date = July 1995 | access-date = 2009-04-05 | url-status = dead | archive-url = https://web.archive.org/web/20090209062022/http://www.dr-bob.org/tips/bzd.html | archive-date = 2009-02-09 }}</ref>

It is fairly important to note that elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Due to increased sensitivity and potentially dangerous [[adverse event]]s among elderly patients, it is recommended to avoid prescribing them as specified by the 2015 [[American Geriatrics Society]] [[Beers Criteria]].<ref>{{cite journal | title = American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults | journal = Journal of the American Geriatrics Society | volume = 63 | issue = 11 | pages = 2227–2246 | date = November 2015 | pmid = 26446832 | doi = 10.1111/jgs.13702 | collaboration = American Geriatrics Society 2015 Beers Criteria Update Expert Panel | s2cid = 38797655 | author1 = By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel | doi-access = free }}</ref>  Individuals with an impaired liver also metabolize benzodiazepines more slowly. Thus, the approximate equivalent of doses below may need to be adjusted accordingly in individuals on short acting benzodiazepines who metabolize long-acting benzodiazepines more slowly and vice versa. The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms.{{cn|date=March 2013}} For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.<ref>{{cite book | vauthors = Salzman C |title=Clinical geriatric psychopharmacology |url=https://books.google.com/books?id=RXvpjJ1Un2gC&pg=PA450 |edition=4th |date=15 May 2004 |publisher=Lippincott Williams & Wilkins |location=USA |isbn=978-0-7817-4380-8 |pages=450–453}}</ref><ref>{{cite journal | vauthors = Delcò F, Tchambaz L, Schlienger R, Drewe J, Krähenbühl S | title = Dose adjustment in patients with liver disease | journal = Drug Safety | volume = 28 | issue = 6 | pages = 529–545 | year = 2005 | pmid = 15924505 | doi = 10.2165/00002018-200528060-00005 | s2cid = 9849818 }}</ref> Equivalent doses of benzodiazepines differ as much as 20 fold.<ref>{{cite journal | vauthors = Riss J, Cloyd J, Gates J, Collins S | title = Benzodiazepines in epilepsy: pharmacology and pharmacokinetics | journal = Acta Neurologica Scandinavica | volume = 118 | issue = 2 | pages = 69–86 | date = August 2008 | pmid = 18384456 | doi = 10.1111/j.1600-0404.2008.01004.x | s2cid = 24453988 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Ashton H | title = Guidelines for the rational use of benzodiazepines. When and what to use | journal = Drugs | volume = 48 | issue = 1 | pages = 25–40 | date = July 1994 | pmid = 7525193 | doi = 10.2165/00003495-199448010-00004 | s2cid = 46966796 }}</ref><ref>{{Cite web|url=https://benzo.org.uk/manual/bzcha01.htm#24|title=benzo.org.uk : Benzodiazepines: How They Work & How to Withdraw, Prof C H Ashton DM, FRCP, 2002|website=benzo.org.uk|access-date=2019-12-19}}</ref>

==Pharmacokinetic properties of various benzodiazepines==
Equivalency data in the table below is taken from the Ashton "Benzodiazepine Equivalence Table".<ref name="Ashton 2007"/><ref name="MHT chart">{{cite web |title=Benzodiazepine Equivalence Chart |url=http://www.mental-health-today.com/rx/benzo.htm |website=www.mental-health-today.com|archive-url=https://web.archive.org/web/20230130205747/http://www.mental-health-today.com/rx/benzo.htm|archive-date=30 January 2023|url-status=dead}}</ref><ref name="BCNC table">{{cite web |title=Benzodiazepine Equivalence Table |url=http://www.bcnc.org.uk/equivalence.html |website=www.bcnc.org.uk |archive-url=https://web.archive.org/web/20150206035118/http://www.bcnc.org.uk/equivalence.html |archive-date=2015-02-06 |date=April 2007}}</ref><ref name="i table">{{cite journal | vauthors = Farinde A |title=Benzodiazepine Equivalency Table |url=https://emedicine.medscape.com/article/2172250-overview |website=Medscape |date=31 July 2018}}</ref>

{{clear right}}

{| class="wikitable sortable" style="float:center; margin-left:3px;text-size:100%; text-align:right"
|-
! data-sort-type="text" |Drug Name || Common Trade Names{{Efn|Not all trade names are listed.|name=|group=}}|| data-sort-type="number" |Year Approved
{{nobold|([[Food and Drug Administration|US FDA]])}}
!Typical Oral Dosage Formulations  
'''{{nobold|(mg)}}'''
! data-sort-type="number" | Approx. Equivalent Oral Dose to 10&nbsp;mg Diazepam{{Efn|An alternative table published by the state of [[South Australia]] uses equivalent approximate oral dosages to 5 mg [[diazepam]].<ref>{{Cite web|url=https://www.sahealth.sa.gov.au/wps/wcm/connect/dbd6d500407749f193d6bb222b2948cf/Benzodiazepines+-+GPs+2017.pdf?MOD=AJPERES&CACHEID=ROOTWORKSPACE-dbd6d500407749f193d6bb222b2948cf-m08aBgI|title=Benzodiazepines Information for GPs |publisher=Drug and Alcohol Services South Australia}}</ref>|name=|group=}} {{nobold|(mg)}}|| data-sort-type="number" |Peak Onset of Action
{{nobold|(hours)}}
! data-sort-type="number" |Elimination Half-life of Active Metabolite {{nobold|(hours)}}|| Primary Therapeutic Use
|-
|[[Adinazolam]]
||Deracyn||{{Maybe|[[Research chemical]]|align=|style=|color=}}
|
| ||1–2||3||[[anxiolytic]], [[antidepressant]]
|-
|[[Alprazolam]]
||Xanax, Helex, Xanor, Trankimazin, Onax, Alprox, Misar, Restyl, Solanax, Tafil, Neurol, Frontin, Kalma, Ksalol, Farmapram||{{Yes|1981|align=|style=|color=}}
|0.25, 0.5, 1, 2
|0.5||1–3<ref name= Moy2012/>||11-13 [10–20]<ref name= Moy2012>{{cite journal | vauthors = Moylan S, Giorlando F, Nordfjærn T, Berk M | title = The role of alprazolam for the treatment of panic disorder in Australia | journal = The Australian and New Zealand Journal of Psychiatry | volume = 46 | issue = 3 | pages = 212–224 | date = March 2012 | pmid = 22391278 | doi = 10.1177/0004867411432074 | s2cid = 11006795 }}</ref>||[[anxiolytic]], [[antidepressant]]<ref>Ashton Manual</ref>
|-
|[[Bentazepam]]{{Efn|Technically this is a [[thienodiazepine]], but produces very similar effects as benzodiazepines.|name=type1|group=}}
||Thiadipona
| 
|25
| ||1–3||2–4||[[anxiolytic]]
|-
|[[Bretazenil]]<ref>{{cite journal | vauthors = van Steveninck AL, Gieschke R, Schoemaker RC, Roncari G, Tuk B, Pieters MS, Breimer DD, Cohen AF | display-authors = 6 | title = Pharmacokinetic and pharmacodynamic interactions of bretazenil and diazepam with alcohol | journal = British Journal of Clinical Pharmacology | volume = 41 | issue = 6 | pages = 565–573 | date = June 1996 | pmid = 8799523 | pmc = 2042631 | doi = 10.1046/j.1365-2125.1996.38514.x }}</ref>
||
| 
|
| ||  ||2.5||[[anxiolytic]], [[anticonvulsant]]
|-
|[[Bromazepam]]
||Lexotanil, Lexotan,  Lexilium, Lectopam, Lexaurin, Lexatin,  Bromam||{{Yes|1981|align=|style=|color=}}
|1.5, 3, 6
|6||1–5||20–40||[[anxiolytic]],
[[hypnotic]], [[muscle relaxant]]
|-
|[[Bromazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|2 , 4
| 2|| || ||[[anxiolytic]]
|-
|[[Brotizolam]]{{Efn|Technically this is a  [[thienotriazolodiazepine]], but produces very similar effects as benzodiazepines.|name=type2|group=}}
||Lendormin, Dormex, Sintonal, Noctilan||
|0.25
|0.5||0.5–2||4–5||[[hypnotic]]
|-
|[[Camazepam]]
||Albego, Limpidon||
|
|40<ref name="ashton"/>||1–3||6–11||[[anxiolytic]]
|-
|[[Chlordiazepoxide]]
||Librium, Risolid, Elenium||{{Yes|1960|align=|style=|color=}}
|5, 10, 25
|25||1.5–6||36–200||[[anxiolytic]]
|-
|[[Cinazepam]]
|Levana||
|0.5, 1, 2
| |||2–4||60||[[hypnotic]], [[anxiolytic]]
|-
|[[Cinolazepam]]
||Gerodorm||
|40
| ||0.5–2||9||[[hypnotic]]
|-
|[[Clobazam]]
||Onfi, Frisium, Urbanol||{{Yes|2011|align=|style=|color=}}
|5, 10, 20
|20 ||1–5||8–60||[[anxiolytic]], [[anticonvulsant]]
|-
|[[Clonazepam]]
||Rivatril, Rivotril, Klonopin, Iktorivil, Paxam||{{Yes|1975|align=|style=|color=}}
|0.5, 1, 2
|0.5-1||1–5
||19.5–50||[[anticonvulsant]], [[anxiolytic]]
|-
|[[Clonazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.25, 0.5
| 0.2||0.5-1||3-4<ref>{{Cite journal |last1=N. Edinoff |first1=Amber |last2=A. Nix |first2=Catherine |last3=S. Odisho |first3=Amira |last4=P. Babin |first4=Caroline |last5=G. Derouen |first5=Alyssa |last6=C. Lutfallah |first6=Salim |last7=M. Cornett |first7=Elyse |last8=Murnane |first8=Kevin S. |last9=M. Kaye |first9=Adam |date=22 August 2022 |editor-last=Müller |editor-first=Thomas |editor2-last=Yamauchi |editor2-first=Junji |title=Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects |journal=Neurology International |volume=14 |issue=3 |page=652 |doi=10.3390/neurolint14030053 |pmid=35997362|pmc=9397074 |doi-access=free }}</ref>||[[hypnotic]], [[anticonvulsant]]
|-
|[[Clorazepate]]
||Tranxene, Tranxilium||{{Yes|1972|align=|style=|color=}}
|3.75, 5, 7.5
|15||Variable||32–152||[[anxiolytic]], [[anticonvulsant]]
|-
|[[Clotiazepam]]{{Efn||name=type1|group=}}
||Veratran, Clozan, Rize||
|5, 10
|10||1–3||4||[[anxiolytic]]
|-
|[[Cloxazolam]]
||Cloxam, Sepazon, Olcadil||
|1, 2, 4
|1.5<ref name="ashton"/> ||2–5||55–77<ref name="ashton"/> ||[[anxiolytic]], [[anticonvulsant]]
|-
|[[Delorazepam]]
||Dadumir||
|0.5, 1, 2
|1-1.5||1–2||79<<ref>{{cite web |title=NMS Labs Report |url=https://www.nmslabs.com/sites/default/files/test-catalog/reports/0570B%40POS.roi_4.pdf |publisher=NMS Labs |access-date=19 April 2022}}</ref>||[[anxiolytic]], [[amnesic]]
|-
|[[Deschloroetizolam]]{{Efn|Technically this is a  [[thienotriazolodiazepine]], but produces very similar effects as benzodiazepines.|name=type2|group=}}
| ||{{Maybe|Research chemical|align=|style=|color=}}
|1, 2
| 4|| || |||[[anxiolytic]]
|-
|[[Diazepam]]
||Antenex, Apaurin, Apzepam, Apozepam, Diazepan, Hexalid, Normabel, Pax, Stesolid, Stedon, Tranquirit, Valium, Vival, Valaxona||{{Yes|1963|align=|style=|color=}}
|2, 5, 10
|10||1–1.5||32–205|||[[anxiolytic]], [[anticonvulsant]], [[muscle relaxant]], [[Amnesia|amnesic]]
|-
|[[Diclazepam]]<ref>{{cite journal | vauthors = Moosmann B, Bisel P, Auwärter V | title = Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics | journal = Drug Testing and Analysis | volume = 6 | issue = 7–8 | pages = 757–763 | year = 2014 | pmid = 24604775 | doi = 10.1002/dta.1628 }}</ref>
| ||{{Maybe|Research chemical|align=|style=|color=}}
|1, 2
| 2||1.5–3||42 ||[[anxiolytic]], [[muscle relaxant]]
|-
|[[Estazolam]]
||ProSom, Nuctalon||{{Yes|1990|align=|style=|color=}}
|1, 2
|2<ref name="ashton"/> ||3–5||10–24||[[hypnotic]], [[anxiolytic]]
|-
|[[Ethyl carfluzepate]]
| ||{{No|Not approved|align=|style=|color=}}
|
|2 ||1–5||11–24||[[hypnotic]]
|-
|[[Etizolam]]{{Efn|Technically this is a  [[thienotriazolodiazepine]], but produces very similar effects as benzodiazepines.|name=type2|group=}}
||Etilaam, Etizest, Pasaden, Depas||{{Maybe|Often sold as a research chemical, but is approved for human use in many countries. Controlled substance in some US states, Canada, Germany, Austria, and others.<ref>{{Cite journal|last=Health Santé Canada|first=Federal Government of Canada|date=January 20, 2012|title=Status Decision of Controlled and Non-Controlled Substances|url=https://isomerdesign.com/Cdsa/HC/StatusDecisions/A-2013-00235%20-%20PDFs/C-Etizolam-23-08-04.pdf|journal=Controlled Drugs and Substances Act |volume=1|pages=2}}</ref><ref>{{Cite web|url=https://iga.in.gov/legislative/2017/bills/house/1019|title=House Bill 1019 - Controlled substances | author = Indiana General Assembly|website=Indiana General Assembly|language=en-US|access-date=2018-02-22}}</ref>|align=|style=|color=}}
|1
|2
|1–3||5-7||[[anxiolytic]], [[muscle relaxant]], [[anticonvulsant]]
|-
|[[Ethyl loflazepate]]
||Victan, Meilax, Ronlax||
|
| 2<ref name="ashton">{{cite web| url=http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html| title=Benzodiazepine Names| access-date=2009-05-31| publisher=non-benzodiazepines.org.uk| url-status=dead| archive-url=https://web.archive.org/web/20081208054743/http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html| archive-date=2008-12-08}}</ref> ||2.5–3||73–119||[[anxiolytic]]
|-
|[[Flualprazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.5, 1
|0.25 ||1-2||12-22 ||[[anxiolytic]], [[hypnotic]]
|-
|[[Flubromazepam]]<ref>{{cite journal | vauthors = Moosmann B, Huppertz LM, Hutter M, Buchwald A, Ferlaino S, Auwärter V | title = Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics | journal = Journal of Mass Spectrometry | volume = 48 | issue = 11 | pages = 1150–1159 | date = November 2013 | pmid = 24259203 | doi = 10.1002/jms.3279 | bibcode = 2013JMSp...48.1150M }}</ref>
| Templex||{{Maybe|Research chemical|align=|style=|color=}}
|4, 8, 12
| 4||1.5–8||100–220||[[anxiolytic]], [[hypnotic]], [[amnesic]], [[muscle relaxant]], [[anticonvulsant]]
|-
|[[Flubromazolam]]
| Remnon||{{Maybe|Research chemical|align=|style=|color=}}
|0.25, 0.5
|0.075 ||0.5-5|| 10-20<ref>{{cite journal | vauthors = Huppertz LM, Moosmann B, Auwärter V | title = Flubromazolam - Basic pharmacokinetic evaluation of a highly potent designer benzodiazepine | journal = Drug Testing and Analysis | volume = 10 | issue = 1 | pages = 206–211 | date = January 2018 | pmid = 28378533 | doi = 10.1002/dta.2203 }}</ref>||[[hypnotic]]
|-
|[[Fluclotizolam]]{{Efn|Technically this is a  [[thienotriazolodiazepine]], but produces very similar effects as benzodiazepines.|name=type2|group=}}
| ||{{Maybe|Research chemical|align=|style=|color=}}
|
|0.25-0.5 || || |||[[anxiolytic]]
|-
|[[Flunitrazepam]]
||Rohypnol, Hipnosedon, Vulbegal, Fluscand, Flunipam, Ronal, Rohydorm, Hypnodorm||{{Yes|1972|align=|style=|color=}}
|1, 2
|1.5
|0.5–3||18–200||[[hypnotic]]
|-
|[[Flunitrazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.25, 0.5
|0.1 ||0.5-1 ||5-13 ||[[hypnotic]]
|-
|[[Flurazepam]]
||Dalmadorm, Dalmane, Fluzepam||{{Yes|1970|align=|style=|color=}}
|30 
|20-25||1–1.5||40–250||[[hypnotic]]
|-
|[[Flutazolam]]
||Coreminal||
|4
| 10||1-3||47-100||[[hypnotic]]
|-
|[[Flutemazepam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|
| 1||0.5-5||8-20||[[hypnotic]], [[anxiolytic]], [[anticonvulsant]], [[muscle relaxant]]<ref name="BZ">{{cite journal | vauthors = Esmailian M, Ahmadi O, Taheri M, Zamani M | title = Comparison of haloperidol and midazolam in restless management of patients referred to the Emergency Department: A double-blinded, randomized clinical trial | journal = Journal of Research in Medical Sciences | volume = 20 | issue = 9 | pages = 844–849 | date = September 2015 | pmc = 6486117 | doi = 10.1002/14651858.CD003079.pub4 | pmid = 29219171 }}</ref>
|-
|[[Flutoprazepam]]
||Restas|| {{Yes|1984|align=|style=|color=}}
|1, 2
| 2.5||0.5–9||87<ref>{{cite journal | vauthors = Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E | title = Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects | journal = European Journal of Drug Metabolism and Pharmacokinetics | volume = 14 | issue = 4 | pages = 293–298 | date = 1989 | pmid = 2633923 | doi = 10.1007/BF03190114 | s2cid = 20710732 }}</ref>||[[hypnotic]], [[anticonvulsant]], [[muscle relaxant]]
|-
|[[Halazepam]]
||Alapryl, Paxipam||{{Yes|1981|align=|style=|color=}}
|20, 40
|40
|3–6||15-35 [30-100]||[[anxiolytic]]
|-
|[[Ketazolam]]
||Anxon, Sedotime||{{Yes|1980|align=|style=|color=}}
|15, 30, 45
|20||2.5–6||30-100 [36-200]||[[anxiolytic]]
|-
|[[Loprazolam]]
||Dormonoct, Havlane||{{Yes|1983|align=|style=|color=}}
|1, 2
|1.5
|2–5||6–20<ref>{{cite journal | vauthors = Swift CG, Swift MR, Ankier SI, Pidgen A, Robinson J | title = Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly | journal = British Journal of Clinical Pharmacology | volume = 20 | issue = 2 | pages = 119–128 | date = August 1985 | pmid = 2864049 | pmc = 1400680 | doi = 10.1111/j.1365-2125.1985.tb05041.x }}</ref>||[[hypnotic]]
|-
|[[Lorazepam]]
||Ativan, Orfidal, Lorenin, Lorsilan, Temesta, Tavor, Lorabenz||{{Yes|1977|align=|style=|color=}}
|0.5, 1, 2, 2.5
|1
||2–4||10–20||[[anxiolytic]], [[anticonvulsant]], [[hypnotic]], [[muscle relaxant]]<ref>{{cite journal | vauthors=Shah D, Borrensen D | title=Benzodiazepines: A Guide to Safe Prescribing | journal=The Carlat Report: Psychiatry | year=2011 | url=http://www.thecarlatreport.com/sites/default/files/2011%20TCPR%20Benzo%20Table.pdf | access-date=2015-06-28 | archive-date=2015-07-01 | archive-url=https://web.archive.org/web/20150701013255/http://www.thecarlatreport.com/sites/default/files/2011%20TCPR%20Benzo%20Table.pdf | url-status=dead }}</ref><ref name="i table" /><ref>{{cite web|url=http://www.vhpharmsci.com/vhformulary/tools/benzodiazepines-comparison.htm |title=Comparison of Benzodiazepines | author= Vancouver Hospital Pharmaceutical Sciences }}</ref>
|-
|[[Lormetazepam]]
||Loramet, Noctamid, Pronoctan|| {{Yes|1984|align=|style=|color=}}
|1, 2
|1.5
|0.5–2||10-12||[[hypnotic]], [[anxiolytic]]
|-
|[[Meclonazepam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|6
| || || |||[[anxiolytic]]
|-
|[[Medazepam]]
||Nobrium, Ansilan, Mezapam, Rudotel, Raporan||
|10
|10
|4-8||36–200||[[anxiolytic]]
|-
|[[Metizolam]]{{Efn|Technically this is a  [[thienotriazolodiazepine]], but produces very similar effects as benzodiazepines.|name=type2|group=}}
| ||{{Maybe|Research chemical|align=|style=|color=}}
|1, 2, 4
|2–4
| ||12||[[anxiolytic]]
|-
|[[Mexazolam]]
||Melex, Sedoxil||
|0.5, 1
| ||1–2|| ||[[anxiolytic]]
|-
|[[Midazolam]]
|| Dormicum, Flormidal, Versed, Hypnovel, Dormonid||{{Yes|1985|align=|style=|color=}}
|7.5, 15
|10 (oral)
4 (IV)
|0.5–1||1.8-6 ||[[hypnotic]], [[anticonvulsant]]
|-
|[[Nifoxipam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.5, 1, 2
| || || ||[[hypnotic]]
|-
|[[Nimetazepam]]
||Erimin, Lavol|| {{Yes|1984|align=|style=|color=}}
|5
|2.5-5||0.5–3||14–30||[[hypnotic]]
|-
|[[Nitemazepam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|
|2 ||0.5-5 ||10-27 || [[hypnotic]], [[anticonvulsant]]
|-
|[[Nitrazepam]]
||Mogadon, Alodorm, Pacisyn, Dumolid, Nitrazadon||{{Yes|1965|align=|style=|color=}}
|5, 10
|5||0.5–7||17–48||[[hypnotic]], [[anticonvulsant]]
|-
|[[Nitrazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.5, 1
| || || ||[[hypnotic]]
|-
|[[Nordiazepam|Nordazepam]]
||Madar, Stilny||
|5, 7.5, 15
|10-15|| ||30–150||[[anxiolytic]]
|-
|[[Norflurazepam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|
|  5||
|47-100
|[[hypnotic]]
|-
|[[Oxazepam]]
||Seresta, Serax, Serenid, Serepax, Sobril, Oxabenz, Oxapax, Oxascand, Ox-Pam, Opamox, Alepam, Medopam, Murelax, Noripam, Purata||{{Yes|1965|align=|style=|color=}}
|10, 15, 30, 50
|30||3–4||4–11||[[anxiolytic]]
|-
|[[Phenazepam]]
|| Phenazepam, Phenzitat||{{Maybe|Research chemical|align=|style=|color=}}
|
| ||1.5–4 ||60||[[anxiolytic]], [[anticonvulsant]]
|-
|[[Pinazepam]]
||Domar, Duna||
|5, 10
| || ||40–100||[[anxiolytic]]
|-
|[[Prazepam]]
||Demetrin, Lysanxia, Prazene, Centrax||{{Yes|1976|align=|style=|color=}}
|10, 20, 30
|15-20
|2–6||36–200||[[anxiolytic]]
|-
|[[Premazepam]]
| ||{{No|Not approved|align=|style=|color=}}
|
|15||2–6||10–13||[[anxiolytic]]
|-
|[[Pyrazolam]]
| ||{{Maybe|Research chemical|align=|style=|color=}}
|0.25, 0.5, 1
| ||1–1.5||16–18<ref>{{cite web | vauthors = Moosmann B, Hutter M, Huppertz LM, Auwärter V |url=http://infoespai.org/MossmannDPHG2013.pdf |title= Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples |access-date=2014-11-05 |url-status=dead |archive-url=https://web.archive.org/web/20141105130415/http://infoespai.org/MossmannDPHG2013.pdf |archive-date=2014-11-05 }}</ref>||[[anxiolytic]], [[amnesic]]
|-
|[[Quazepam]]
||Doral, Quiedorm||{{Yes|1985|align=|style=|color=}}
|15
|20||1–5||39–120||[[hypnotic]]
|-
|[[Rilmazafone]]
||Rhythmy||
|
| || ||11||[[hypnotic]]
|-
|[[Temazepam]]
||Restoril, Normison, Euhypnos, Temaze, Tenox||{{Yes|1981|align=|style=|color=}}
|10, 20
|15-20||0.5–3||4–11||[[hypnotic]], [[anxiolytic]], [[muscle relaxant]]
|-
|[[Tetrazepam]]
||Myolastan, Clinoxam, Epsipam, Musaril||
|50
| ||1–3||3–26 ||[[muscle relaxant]], [[anxiolytic]]
|-
|[[Triazolam]]
||Halcion, Rilamir, Notison, Somese||{{Yes|1980|align=|style=|color=}}
|0.125, 0.25
|0.5||0.5–2||2||[[hypnotic]]
|-
!Drug Name !!Common Trade Names !!Year Approved 
!Typical Dosages of Oral Tablets
'''{{nobold|(mg)}}'''
!Approx. Equivalent Oral Dose to 10mg Diazepam {{nobold|(mg)}} !!Peak onset of action {{nobold|(hours)}} !!Elimination Half-life of Active Metabolite {{nobold|(hours)}} !!Primary Therapeutic Use
|}

===Atypical benzodiazepine receptor ligands===
{| class="wikitable sortable" style="float:center; margin-left:3px;text-size:100%; text-align:right"
|-
!Drug Name !! Common Trade Names !! Year approved ([[Food and Drug Administration|US FDA]]) !! Elimination Half-life of Active Metabolite {{nobold|(hours)}} !! Primary Therapeutic Use
|-
|[[DMCM]] ||  ||  ||  ||[[anxiogenic]], [[convulsant]]
|-
|[[Flumazenil]]{{Efn|Flumazenil is an imidazobenzodiazepine derivative,<ref name="autogenerated1">{{cite web | url = https://www.gene.com/download/pdf/romazicon_prescribing.pdf | title = Romazicon 2 (flumazenil) 3 Injection | publisher = Genentech, Inc. }}</ref> and in layman's terms, it is a benzodiazepine overdose antidote that is given intravenously in Intensive Care Units (ICUs) to reverse the effects of benzodiazepine overdoses, as well for overdoses of the non-benzodiazepine "Z-drugs" such as zolpidem.<ref name = "DailyMed_Flumazenil">{{cite web |url= https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=11882e93-aa62-4d24-895c-6f01d97fc730 |title=Flumazenil Injection, Solution [App Pharmaceuticals, Llc&#93;| work = DailyMed | publisher = U.S. National Library of Medicine |access-date=2014-08-15}}</ref> Flumazenil is contraindicated for benzodiazepine-tolerant patients in overdose cases.<ref name = "DailyMed_Flumazenil" /> In such cases, the benefits are far outweighed by the risks, which include potential and severe seizures.<ref name="autogenerated1" /><ref>{{cite book | vauthors = Fleisher GR, Ludwig S, Silverman BK | date = 2002 | title = Synopsis of pediatric emergency medicine. | publisher = Lippincott Williams & Wilkins. | page = 409 | isbn = 978-0-7817-3274-1 }}</ref> The method by which flumazenil acts to prevent non-benzodiazepine tolerant overdose from causing potential harm is via preventing the benzodiazepines and Z-drugs from binding to the GABA<sub>A</sub> receptors via competitive inhibition which the flumazenil creates. Clinical observation notating the patient's oxygen levels, respiratory, heart and blood pressure rates are used, as they are much safer than the potential seizure effects from flumazenil. Supportive care to mediate any problems resulting from abnormal rates of the pulmonary, respiratory, and cardiovascular systems is typically the only treatment that is required in benzodiazepine-only overdoses.<ref name="inchem1">{{cite web | url = http://www.inchem.org/documents/pims/pharm/pim181.htm#DivisionTitle:8.1.1.1 | title = Toxicological analyses | access-date = 21 March 2013 }}</ref> In most cases, activated charcoal/carbon is often used to prevent benzodiazepines from being absorbed by the gastrointestinal tract, and the use of stomach-pumping/gastric lavage is no longer commonly used nor suggested by some toxicologists.<ref>{{cite journal | vauthors = Vale JA, Kulig K | title = Position paper: gastric lavage | journal = Journal of Toxicology. Clinical Toxicology | volume = 42 | issue = 7 | pages = 933–943 | year = 2004 | pmid = 15641639 | doi = 10.1081/CLT-200045006 | s2cid = 29957973 }}</ref> Even in cases where other central nervous system (CNS) depressants (such as in combined benzodiazepine and tricyclic antidepressant/TCA overdoses) are detected and/or suspected, endotrachial intubation for the airway path and supportive oxygen are typically implemented and are much safer than flumazenil.<ref name="inchem1" />|name=|group=}}|| Anexate, Lanexat, Mazicon, Romazicon || || 1 ||[[antidote]]
|-
|[[Eszopiclone]]<sup>§</sup> || Lunesta || 2004 || 6 ||[[hypnotic]]
|-
|[[Zaleplon]]<sup>§</sup> || Sonata, Starnoc || 1999 || 1 ||[[hypnotic]]
|-
|[[Zolpidem]]<sup>§</sup> || Ambien, Nytamel, Sanval, Stilnoct, Stilnox, Sublinox (Canada), Xolnox, Zoldem, Zolnod || 1992 || 2.6 ||[[hypnotic]]
|-
|[[Zopiclone]]<sup>§</sup> || Imovane, Rhovane, Ximovan; Zileze; Zimoclone; Zimovane; Zopitan; Zorclone, Zopiklone || || 4–6 ||[[hypnotic]]
|}
{{Notelist}}

===Controversy===
In 2015 the UK's House of Commons attempted to get a two to four week limit mandate for prescribing benzodiazepines to replace the two to four week benzodiazepine prescribing guidelines, which are merely recommended.<ref>{{cite web |url=http://www.benzo.org.uk/appg.htm |title=APPG for Involuntary Tranquilliser Addiction |publisher=benzo.org.uk |access-date=21 March 2015}}</ref>

==Binding data and structure-activity relationship==
[[File:Benzodiazépines en France.jpg|thumb|A variety of Benzodiazepines along with their molecular structure.]]
A large number of [[benzodiazepine]] derivatives have been synthesised and their [[structure-activity relationship]]s explored in detail.<ref>{{cite journal | vauthors = Sternbach LH | title = The benzodiazepine story | journal = Journal of Medicinal Chemistry | volume = 22 | issue = 1 | pages = 1–7 | date = January 1979 | pmid = 34039 | doi = 10.1021/jm00187a001 }}</ref><ref>{{cite journal |vauthors=Hadjipavlou-Litina D, Hansch C | year = 1994 | title = Quantitative structure-activity relationships of the benzodiazepines. a review and reevaluation | journal = Chemical Reviews | volume = 94 | issue = 6| pages = 1483–1505 | doi = 10.1021/cr00030a002 }}</ref><ref>Edinoff AN, Nix CA, Odisho AS, Babin CP, Derouen AG, Lutfallah SC, Cornett EM, Murnane KS, Kaye AM, Kaye AD. Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects. ''Neurol Int''. 2022 Aug 22;14(3):648-663. {{doi|10.3390/neurolint14030053}} {{PMID|35997362}}</ref><ref>Yu X, Greenblatt HK, Greenblatt DJ. Designer benzodiazepines: an update. ''Expert Rev Clin Pharmacol''. 2023 Feb;16(2):109-117. {{doi|10.1080/17512433.2023.2170349}} {{PMID|36649662}}</ref> This chart contains binding data for benzodiazepines and related drugs investigated by [[Hoffmann-La Roche|Roche]] up to the late 1990s (though in some cases the compounds were originally synthesised by other companies such as [[Takeda Pharmaceutical Company|Takeda]] or [[Upjohn]]).<ref>{{cite journal | vauthors = Haefely W, Kyburz E, Gerecke M, Mohler H | year =1985 | title = Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationships of their agonists and antagonists | journal = Adv. Drug Res | volume = 1985 | issue = 14| pages = 165–322 }}</ref><ref>{{cite journal | vauthors = Winkler DA, Burden FR, Watkins AJ |title=Atomistic Topological Indices Applied to Benzodiazepines using Various Regression Methods |journal=Quantitative Structure-Activity Relationships |date=January 1998 |volume=17 |issue=1 |pages=14–19 |doi=10.1002/(SICI)1521-3838(199801)17:01<14::AID-QSAR14>3.0.CO;2-U}}</ref><ref>{{cite journal | vauthors = Thakur A, Thakur M, Khadikar P | title = Topological modeling of benzodiazepine receptor binding | journal = Bioorganic & Medicinal Chemistry | volume = 11 | issue = 23 | pages = 5203–5207 | date = November 2003 | pmid = 14604684 | doi = 10.1016/j.bmc.2003.08.014 }}</ref><ref>{{cite journal | vauthors = So SS, Karplus M | title = Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors | journal = Journal of Medicinal Chemistry | volume = 39 | issue = 26 | pages = 5246–5256 | date = December 1996 | pmid = 8978853 | doi = 10.1021/jm960536o }}</ref><ref>{{cite book | vauthors = Braestrup C, Nielsen M | chapter = Benzodiazepine receptors. Biochemical Studies of CNS Receptors | veditors = Iversen LL, Iversen SD, Snyder SH | title = Handbook of Psychopharmacology | date = 1983 | publisher = Springer | isbn = 9781468443615 }}</ref><ref>{{cite book | vauthors = Zhang W, Diaz-Arauzo H, Allen MS, Koehler KF, Cook JM | chapter = Chapter 7: Chemical and computer assisted development of the inclusive pharmacophore of benzodiazepine receptors. | title = Studies in Medicinal Chemistry | veditors = Choudhary MI | date = 1996 | pages = 303 | publisher = CRC Press | isbn = 9783718658794 }}</ref> Other benzodiazepines are also listed for comparison purposes,<ref>{{cite journal | vauthors = Obradović AL, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM | display-authors = 6 | title = Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects | journal = Brain Research | volume = 1554 | pages = 36–48 | date = March 2014 | pmid = 24472579 | pmc = 3996760 | doi = 10.1016/j.brainres.2014.01.036 }}</ref><ref>{{cite journal | vauthors = Cornett EM, Novitch MB, Brunk AJ, Davidson KS, Menard BL, Urman RD, Kaye AD | title = New benzodiazepines for sedation | journal = Best Practice & Research. Clinical Anaesthesiology | volume = 32 | issue = 2 | pages = 149–164 | date = June 2018 | pmid = 30322456 | doi = 10.1016/j.bpa.2018.06.007 | s2cid = 53501694 }}</ref><ref>{{cite journal | vauthors = Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM | display-authors = 6 | title = A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model | journal = International Journal of Medicinal Chemistry | volume = 2015 | pages = 430248 | year = 2015 | pmid = 26682068 | pmc = 4657098 | doi = 10.1155/2015/430248 | doi-access = free }}</ref> but it does not however include binding data for;
* Benzodiazepines developed in the former Soviet Union (e.g. [[phenazepam]], [[gidazepam]] etc.)
* Benzodiazepines predominantly used only in Japan (e.g. [[nimetazepam]], [[flutoprazepam]] etc.)
* 4,5-cyclised benzodiazepines (e.g. [[ketazolam]], [[cloxazolam]] etc.), and other compounds not researched by Roche
* Benzodiazepines developed more recently (e.g. [[remimazolam]], [[QH-ii-066]], [[Ro48-6791]] etc.)
* "Designer" benzodiazepines for which ''in vitro'' binding data are unavailable (e.g. [[flubromazolam]], [[pyrazolam]] etc.)<ref>{{cite journal | vauthors = Moosmann B, King LA, Auwärter V | title = Designer benzodiazepines: A new challenge | journal = World Psychiatry | volume = 14 | issue = 2 | pages = 248 | date = June 2015 | pmid = 26043347 | pmc = 4471986 | doi = 10.1002/wps.20236 }}</ref><ref name="Moosmann_2018">{{cite book | vauthors = Moosmann B, Auwärter V | title = New Psychoactive Substances | chapter = Designer Benzodiazepines: Another Class of New Psychoactive Substances | series = Handbook of Experimental Pharmacology | volume = 252 | pages = 383–410 | date = 2018 | pmid = 30367253 | doi = 10.1007/164_2018_154 | isbn = 978-3-030-10560-0 | veditors = Maurer H, Brandt S }}</ref><ref>{{cite journal | vauthors = Manchester KR, Lomas EC, Waters L, Dempsey FC, Maskell PD | title = The emergence of new psychoactive substance (NPS) benzodiazepines: A review | journal = Drug Testing and Analysis | volume = 10 | issue = 1 | pages = 37–53 | date = January 2018 | pmid = 28471096 | doi = 10.1002/dta.2211 | url = https://rke.abertay.ac.uk/en/publications/9a280549-be8d-4907-b7d4-532fbfd8547a | doi-access = free }}</ref><ref>{{cite journal | vauthors = Waters L, Manchester KR, Maskell PD, Haegeman C, Haider S | title = The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines | journal = Science & Justice | volume = 58 | issue = 3 | pages = 219–225 | date = May 2018 | pmid = 29685303 | doi = 10.1016/j.scijus.2017.12.004 | url = https://rke.abertay.ac.uk/en/publications/cc950cf1-155d-40c9-8068-9b17cd84cbec }}</ref><ref>{{cite journal | vauthors = Zawilska JB, Wojcieszak J | title = An expanding world of new psychoactive substances-designer benzodiazepines | journal = Neurotoxicology | volume = 73 | pages = 8–16 | date = July 2019 | pmid = 30802466 | doi = 10.1016/j.neuro.2019.02.015 | s2cid = 73461430 }}</ref>
While binding or activity data are available for most of these compounds also, the assay conditions vary between sources, meaning that in many cases the values are not suitable for a direct comparison. Many older sources used animal measures of activity (i.e. sedation or anticonvulsant activity) but did not measure ''in vitro'' binding to benzodiazepine receptors.<ref>{{cite journal | vauthors = Blair T, Webb GA | title = Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones | journal = Journal of Medicinal Chemistry | volume = 20 | issue = 9 | pages = 1206–1210 | date = September 1977 | pmid = 926122 | doi = 10.1021/jm00219a019 }}</ref><ref>{{cite journal | vauthors = Biagi GL, Barbaro AM, Guerra MC, Babbini M, Gaiardi M, Bartoletti M, Borea PA | title = Rm values and structure-activity relationship of benzodiazepines | journal = Journal of Medicinal Chemistry | volume = 23 | issue = 2 | pages = 193–201 | date = February 1980 | pmid = 7359533 | doi = 10.1021/jm00176a016 }}</ref> See for instance Table 2 vs Table 11 in the ''Chem Rev'' paper, Table 2 lists ''in vitro'' pIC<sub>50</sub> values matching those below, while Table 11 has pEC<sub>50</sub> values derived from ''in vivo'' assays in mice, which show the same activity trends but cannot be compared directly, and includes data for compounds such as [[diclazepam]] and [[flubromazepam]] which are not available in the main data set.


Also note;
* IC<sub>50</sub> / pIC<sub>50</sub> values represent binding affinity only and do not reflect efficacy or pharmacokinetics, and some compounds listed are GABA<sub>A</sub> antagonists rather than agonists (e.g. [[flumazenil]]).
* Low IC<sub>50</sub> or high pIC<sub>50</sub> values indicate tighter binding (pIC<sub>50</sub> of 8.0 = IC<sub>50</sub> of 10nM, pIC<sub>50</sub> of 9.0 = IC<sub>50</sub> of 1nM, etc.)
* These are non subtype selective IC<sub>50</sub> values averaged across all GABA<sub>A</sub> receptor [[GABAA receptor#Subunits|subtypes]], so subtype selective compounds with strong binding at one subtype but weak at others will appear unusually weak due to averaging of binding values (see e.g. [[CL-218,872]])
* <sup>†</sup> indicates a predicted value from ''in silico'' modelling.<ref>Catalani V, Floresta G, Botha M, Corkery JM, Guirguis A, Vento A, Abbate V, Schifano F. In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines. ''Chem Biol Drug Des''. 2023 Jan;101(1):40-51. {{doi|10.1111/cbdd.14119}} {{PMID|35838189}}</ref>
* Finally, note that the benzodiazepine core is a [[privileged scaffold]], which has been used to derive drugs with diverse activity that is not limited to the GABA<sub>A</sub> modulatory action of the classical benzodiazepines,<ref>{{cite journal | vauthors = Spencer J, Rathnam RP, Chowdhry BZ | title = 1,4-Benzodiazepin-2-ones in medicinal chemistry | journal = Future Medicinal Chemistry | volume = 2 | issue = 9 | pages = 1441–1449 | date = September 2010 | pmid = 21426139 | doi = 10.4155/fmc.10.226 }}</ref> such as [[devazepide]] and [[tifluadom]], however these have not been included in the list below. 2,3-benzodiazepines such as [[tofisopam]] are also not listed, as these act primarily as [[AMPA receptor]] modulators, and are inactive at GABA<sub>A</sub> receptors.

== Table ==
{| class="talk collapsed collapsible"
|-
! scope="col" | Table of benzodiazepines
|- style="text-align: left;"
|
{| class="wikitable sortable"
|-
! scope="col" class="unsortable" | Chemical structure
! scope="col" | Code
! scope="col" class="unsortable" | pIC<sub>50</sub> / IC<sub>50</sub>
! scope="col" class="unsortable" | Chemical name
! scope="col" class="unsortable" | PubChem
! scope="col" class="unsortable" | CAS number
|-
| [[File:Ro05-3061_structure.png|120px]] || Ro05-3061 || 7.3979 / 40nM || 7-fluoro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/75849 75849] || 2648-00-2
|-
| [[File:Ro05-4865_structure.png|120px]] || Ro05-4865 || 7.7696 / 17nM || 7-fluoro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366179 44366179] ||
|-
| [[File:Ro05-6820_structure.png|120px]] || Ro05-6820 || 8.1308 / 7.4nM || 7-fluoro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366116 44366116] ||
|-
| [[File:Ro05-6822_structure.png|120px]] || Ro05-6822 || 8.2924 / 5.1nM || 7-fluoro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/23275675 23275675] || 2024-34-2
|-
| [[File:Flubromazepam isomer.svg|120px]] || Iso-flubromazepam ||  || 7-fluoro-5-(2-bromophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/15292433 15292433] || 153873-96-2
|-
| [[File:Nordazepam.svg|120px]] || [[Nordazepam]] || 8.0269 / 9.4nM || 7-chloro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2997 2997] || 1088-11-5
|-
| [[File:Diazepam structure.svg|120px]] || [[Diazepam]] || 8.0915 / 8.1nM || 7-chloro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3016 3016] || 439-14-5
|-
| [[File:Desalkylflurazepam.svg|120px]] || [[Norflurazepam]] (Ro05-3367) || 8.699 || 7-chloro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/4540 4540] || 2886-65-9
|-
| [[File:Fludiazepam.svg|120px]] || [[Fludiazepam]] ||  || 7-chloro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/3369 3369] || 3900-31-0
|-
| [[File:Ro07-3953_structure.png|120px]] || Ro07-3953 || 8.7959 / 1.6nM || 7-chloro-5-(2,6-difluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/23275763 23275763] ||
|-
| [[File:Difludiazepam_structure.png|120px]] || [[Difludiazepam]] (Ro07-4065) || 8.3872 / 4.1nM || 7-chloro-5-(2,6-difluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366236 44366236] || 39080-67-6
|-
| [[File:Delorazepam 200.svg|120px]] || [[Delorazepam]] || 8.7447 / 1.8nM || 7-chloro-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=17925 17925] || 2894-67-9
|-
| [[File:Diclazepam structure.svg|120px]] || [[Diclazepam]] (Ro05-3448) || 7.8 <sup>†</sup> || 7-chloro-5-(2-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76168 76168] || 2894-68-0
|-
| [[File:Ro5-4864.svg|120px]] || [[Ro05-4864]] || TSPO ligand || 7-chloro-5-(4-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1688 1688] || 14439-61-3
|-
| [[File:Ro07-5193_structure.png|120px]] || Ro07-5193 || 8.5229 || 7-chloro-5-(2-chloro-6-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366219 44366219] ||
|-
| [[File:Ro22-3294_structure.png|120px]] || Ro22-3294 || 8.1549 || 7-chloro-5-(2,6-dichlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/12790028 12790028] ||
|-
| [[File:Ro07-5220_structure.png|120px]] || [[Ro07-5220]] || 8.2596 || 7-chloro-5-(2,6-dichlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/9975396 9975396] || 30144-88-8
|-
| [[File:Desalkylgidazepam.svg|120px]] || 7-BPDBD || 7.8 <sup>†</sup> || 7-bromo-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=76167 76167] || 2894-61-3
|-
| [[File:QH-II-063_structure.png|120px]] || QH-II-063 ||  || 7-bromo-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=627432 627432] || 28611-28-1
|-
| [[File:Phenazepam.svg|120px]] || [[Phenazepam]] || 8.4 <sup>†</sup> || 7-bromo-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=40113 40113] || 51753-57-2
|-
| [[File:Flubromazepam.svg|120px]] || [[Flubromazepam]] (JYI-42) || 7.6 <sup>†</sup> || 7-bromo-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12947024 12947024] || 2647-50-9
|-
| [[File:Flubrometazepam_structure.png|120px]] || Flubrometazepam ||  || 7-bromo-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=135809 135809] || 86890-79-1
|-
| [[File:SH-I-048A_structure.png|120px]] || [[SH-I-048A]] ||  || (3S)-7-bromo-5-(2-fluorophenyl)-3-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=49850464 49850464]  || 872874-11-8
|-
| [[File:Gidazepam.svg|120px]] || [[Gidazepam]] || 6.4 <sup>†</sup> || 2-(7-bromo-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-1-yl)acetohydrazide || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=121919 121919] || 129186-29-4
|-
| [[File:Ro13-3780_structure.png|120px]] || Ro13-3780 || 8.6198 || 7-bromo-5-(2,6-difluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/9975396 9975396] || 103380-73-0
|-
| [[File:Ro07-9749_structure.png|120px]] || [[Ro07-9749]] ||   || 7-iodo-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/3082318 3082318] || 30843-56-2
|-
| [[File:Ro07-9957_structure.png|120px]] || Ro07-9957 || 8.5376 || 7-iodo-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/118749 118749] ||
|-
| [[File:Triflunordazepam.svg|120px]] || [[Ro05-2904]] || 7.8861 / 13nM || 7-trifluoromethyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/16795 16795] || 2285-16-7
|-
| [[File:Ro14-3074_structure.png|120px]] || Ro14-3074 || 8.2757 / 5.3nM || 7-azido-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Nitrazepam.svg|120px]] || [[Nitrazepam]] || 8.0 / 10nM || 7-nitro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4506 4506] || 146-22-5
|-
| [[File:Nimetazepam.svg|120px]] || [[Nimetazepam]] ||  || 7-nitro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4496 4496] || 2011-67-8
|-
| [[File:Desmethylflunitrazepam.svg|120px]] || [[Ro05-4435]] || 8.829 / 1.5nM || 7-nitro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/520217 520217] || 2558-30-7
|-
| [[File:Flunitrazepam structure.svg|120px]] || [[Flunitrazepam]] || 8.4202 / 3.8nM || 7-nitro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3380 3380] || 1622-62-4
|-
| [[File:Clonazepam 200.svg|120px]] || [[Clonazepam]] || 8.7447 / 1.8nM || 7-nitro-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2802 2802] || 1622-61-3
|-
| [[File:Ro05-4082_structure.png|120px]] || [[Ro05-4082]] || 8.6576 || 7-nitro-5-(2-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/528222 528222] || 5527-71-9
|-
| [[File:Ro05-3590_structure.png|120px]] || Ro05-3590 || 8.4559 / 3.5nM || 7-nitro-5-[2-(trifluoromethyl)phenyl]-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/15024 15024] || 1427-45-8
|-
| [[File:QH-146_structure.png|120px]] || QH-146 ||   || 7-nitro-5-(2-nitrophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44383992 44383992] || 
|-
| [[File:Ro20-7736_structure.png|120px]] || Ro20-7736 || 7.0177 / 96nM || 7-hydroxyamino-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro05-3072_structure.png|120px]] || Ro05-3072 || 6.4134 / 386nM || 7-amino-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/78641 78641] || 4928-02-3
|-
| [[File:Ro05-4318_structure.png|120px]] || Ro05-4318 || 6.3372 / 460nM || 7-amino-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/23275339 23275339] || 4959-16-4
|-
| [[File:Ro20-1815_structure.png|120px]] || Ro20-1815 || 7.1871 / 65nM || 7-amino-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/92294 92294] || 34084-50-9
|-
| [[File:Ro05-4619_structure.png|120px]] || Ro05-4619 || 7.1249 / 75nM || 7-amino-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/188298 188298] || 4959-17-5
|-
|  || Ro05-3308 || IC<sub>50</sub> >1000nM || N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-7-yl)acetamide ||  ||
|-
|  || Ro12-6377 || 7.1249 / 455nM || 1-(5-(2-fluorophenyl)-1-methyl-2-oxo-2,5-dihydro-1H-benzo[e] [1,4]diazepin-7-yl)-3-methylurea ||  ||
|-
| [[File:Ro05-9090_structure.png|120px]] || Ro05-9090 || IC<sub>50</sub> >1000nM || 7-(aminomethyl)-1-methyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro05-3343_structure.png|120px]] || Ro05-3343 || IC<sub>50</sub> >1000nM || N,N-dimethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepine-7-sulfonamide || [https://pubchem.ncbi.nlm.nih.gov/compound/214460 214460] || 12037-79-5
|-
| [[File:Ro05-4528_structure.png|120px]] || Ro05-4528 || 6.4202 / 380nM || 7-cyano-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro20-2541_structure.png|120px]] || Ro20-2541 || 7.5229 / 30nM || 7-cyano-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro20-2533_structure.png|120px]] || Ro20-2533 || 7.4437 / 36nM || 7-ethyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/10264786 10264786] ||
|-
| [[File:Ro20-5747_structure.png|120px]] || Ro20-5747 || 7.6198 / 24nM || 7-vinyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366036 44366036] ||
|-
| [[File:QH-II-66.svg|120px]] || [[QH-ii-066]] || 7.4 <sup>†</sup> || 7-ethynyl-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9838431 9838431] || 183239-39-6
|-
| [[File:OMB-18_structure.png|120px]] || OMB-18 ||  || 7-ethynyl-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=89276170 89276170] || 
|-
| [[File:XLI-352_structure.png|120px]] || XLI-352 ||  || 7-ethynyl-5-(2-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21065236 21065236] || 
|-
| [[File:Ro20-5397_structure.png|120px]] || Ro20-5397 || 7.3665 / 43nM || 7-formyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro20-3053_structure.png|120px]] || Ro20-3053 || 7.7447 / 18nM || 7-acetyl-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/21828109 21828109] ||
|-
| [[File:Ro05-2921_structure.png|120px]] || Ro05-2921 || 6.4559 / 350nM || 5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/76175 76175] || 2898-08-0
|-
| [[File:Ro05-3663_structure.png|120px]] || Ro05-3663 || IC<sub>50</sub> >1000nM || 5-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/5080 5080] || 70656-87-0
|-
| [[File:Ro05-4336_structure.png|120px]] || Ro05-4336 || 7.6778 / 21nM || 5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/13292074 13292074] ||
|-
| [[File:Ro07-4419_structure.png|120px]] || Ro07-4419 || 7.7212 / 19nM || 5-(2,6-difluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366255 44366255] ||
|-
| [[File:Ro05-4520_structure.png|120px]] || Ro05-4520 || 7.8539 / 14nM || 5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/193319 193319] || 844-11-1
|-
| [[File:Ro05-4608_structure.png|120px]] || Ro05-4608  || 8.4202 || 5-(2-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/10469149 10469149] ||
|-
| [[File:Ro05-3546_structure.png|120px]] || Ro05-3546 || 6.4949 / 320nM || 6-chloro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/14590445 14590445] ||
|-
| [[File:Ro13-0699_structure.png|120px]] || Ro13-0699 || 6.8239 / 150nM || 6-chloro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44377764 44377764]  ||
|-
| [[File:Ro07-6198_structure.png|120px]] || Ro07-6198 || 7.5528 / 28nM || 8-chloro-5-(2,6-difluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/23275762 23275762] ||
|-
| [[File:Ro20-8895_structure.png|120px]] || Ro20-8895 || 7.7212 / 19nM || 8-methyl-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366169 44366169] ||
|-
| [[File:Ro13-0593_structure.png|120px]] || Ro13-0593 || 7.1427 / 72nM || 9-chloro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro13-0882_structure.png|120px]] || Ro13-0882 || IC<sub>50</sub> 300nM || 6,8-dichloro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro22-6762_structure.png|120px]] || Ro22-6762 || 7.3979 / 40nM || 7,8-dichloro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366089 44366089] ||
|-
| [[File:Ro20-8065_structure.png|120px]] || [[Ro20-8065]] || 8.4437 / 3.6nM || 7,8-dichloro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/10358803 10358803] || 88695-06-1
|-
| [[File:Ro20-8552_structure.png|120px]] || [[Ro20-8552]] || 7.8539 / 14nM || 7-methyl-8-chloro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/44366138 44366138] ||
|-
| [[File:Ro05-2750_structure.png|120px]] || Ro05-2750 || 7.4318 / 37nM || 6,8-dichloro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro14-2312_structure.png|120px]] || Ro14-2312 || IC<sub>50</sub> >1000nM || 6-amino-8-chloro-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
|  || Ro07-3609 || 7.284 ||  ||  ||
|-
| [[File:Ro11-8125_structure.png|120px]] || Ro11-8125 || 7.4318 / 37nM || 5-(2-chlorophenyl)-1H-thieno[2,3-e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro08-6739_structure.png|120px]] || Ro08-6739 || IC<sub>50</sub> 70nM || 7-chloro-5-phenyl-1H-thieno[2,3-e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro09-9212_structure.png|120px]] || [[Ro09-9212]] || 8.4089 / 3.9nM || 7-chloro-5-(2-chlorophenyl)-1H-thieno[2,3-e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/135721042 135721042] ||
|-
| [[File:Ro10-2643_structure.png|120px]] || Ro10-2643 || IC<sub>50</sub> 9.4nM || 7-chloro-5-(2-chlorophenyl)-1H-thieno[3,2-e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Clotiazepam.svg|120px]] || [[Clotiazepam]] || || 7-ethyl-5-(2-chlorophenyl)-1-methyl-1H-thieno[2,3-e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/2811 2811] || 33671-46-4
|-
| [[File:Bentazepam.svg|120px]] || [[Bentazepam]] || 8.5 <sup>†</sup> || 5-phenyl-3,5a,6,7,8,9-hexahydro-2H-[1]benzothieno[2,3-e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/34592 34592] || 29462-18-8
|-
| [[File:Lopirazepam.svg|120px]] || [[Lopirazepam]] || || 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-pyrido[3,2-e] [1,4]diazepin-2-one || [https://pubchem.ncbi.nlm.nih.gov/compound/68672 68672] || 42863-81-0
|-
| [[File:Premazepam.svg|120px]] || [[Premazepam]] || 6.7696 / 170nM || 6,7-dimethyl-5-phenyl-3,7-dihydropyrrolo[3,4-e] [1,4]diazepin-2(1H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=72104 72104] || 57435-86-6
|-
| [[File:Ripazepam.svg|120px]] || [[Ripazepam]] ||  || 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e] [1,4]diazepin-5(1H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=33474 33474] || 26308-28-1
|-
| [[File:Zolazepam.svg|120px]] || [[Zolazepam]] ||  || 1,3,8-trimethyl-4-(2-fluorophenyl)-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=35775 35775] || 31352-82-6
|-
| [[File:Zomebazam structure.svg|120px]] || [[Zomebazam]] || 8.1 <sup>†</sup> || 1,3,8-trimethyl-4-phenyl-6,8-dihydropyrazolo[4,3-b] [1,4]diazepine-5,7(1H,4H)-dione || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=132677 132677] || 78466-70-3
|-
| [[File:Ro17-2221_structure.png|120px]] || Ro17-2221 || 6.585 / 260nM || 1-(2-aminoethyl)-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
|  || Ro07-5096 || IC<sub>50</sub> >1000nM || 2-(7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-1-yl)acetic acid ||  ||
|-
|  || Ro08-3026 || 7.2007 ||  ||  ||
|-
| [[File:Halazepam.svg|120px]] || [[Halazepam]] || 7.0362 / 92nM || 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=31640 31640] || 23092-17-3
|-
| [[File:Quazepam.svg|120px]] || [[Quazepam]] ||   || 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-thione || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4999 4999] || 36735-22-5
|-
| [[File:Fletazepam.svg|120px]] || [[Fletazepam]] ||   || 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1H-benzo[e] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=36834 36834] || 34482-99-0
|-
| [[File:Pinazepam.svg|120px]] || [[Pinazepam]]  || 7.0339 / 92.5nM || 7-chloro-5-phenyl-1-(prop-2-yn-1-yl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=40391 40391] || 52463-83-9
|-
| [[File:Prazepam.svg|120px]] || [[Prazepam]] || IC<sub>50</sub> 110nM || 7-chloro-5-phenyl-1-cyclopropylmethyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4890 4890] || 2955-38-6
|-
| [[File:Flutoprazepam.svg|120px]] || [[Flutoprazepam]] || 6.6 <sup>†</sup> || 7-chloro-5-(2-fluorophenyl)-1-cyclopropylmethyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3400 3400] || 25967-29-7
|-
| [[File:Cloniprazepam.svg|120px]] || [[Cloniprazepam]] || 7.8 <sup>†</sup> || 7-nitro-5-(2-chlorophenyl)-1-cyclopropylmethyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||   ||  
|-
| [[File:Ro20-1310_structure.png|120px]] || Ro20-1310 || 6.2076 / 620nM || 7-chloro-5-phenyl-1-(t-butyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Fosazepam.svg|120px]] || [[Fosazepam]] ||  || 7-chloro-5-phenyl-1-(dimethylphosphorylmethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=37114 37114] || 35322-07-7
|-
| [[File:Iclazepam.svg|120px]] || [[Iclazepam]] ||  || 7-chloro-5-phenyl-1-[2-(cyclopropylmethoxy)ethyl]-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=68777 68777] || 57916-70-8
|-
| [[File:Tolufazepam.svg|120px]] || [[Tolufazepam]] ||  || 7-chloro-5-(2-chlorophenyl)-1-[2-(4-methylphenyl)sulfonylethyl]-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=65647 65647] || 86273-92-9
|-
| [[File:Elfazepam.svg|120px]] || [[Elfazepam]] || 6.9 <sup>†</sup> || 7-chloro-5-(2-fluorophenyl)-1-(2-ethylsulfonylethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=65445 65445] || 52042-01-0
|-
| [[File:Reclazepam.svg|120px]] || [[Reclazepam]] ||  || 2-[7-chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]-1,3-oxazol-4(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3052777 3052777] || 76053-16-2
|-
| [[File:Ro07-1986_structure.png|120px]] || Ro07-1986 || 8.0809 / 8.3nM || 1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Flurazepam.svg|120px]] || [[Flurazepam]] || 7.8297 || 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3393 3393] || 17617-23-1
|-
| [[File:Ro07-2750_structure.png|120px]] || Ro07-2750 || 7.6108 / 24.5nM || 7-chloro-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Motrazepam structure.svg|120px]] || [[Motrazepam]] || IC<sub>50</sub> 430nM || 1-(methoxymethyl)-7-nitro-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=65764 65764] || 29442-58-8
|-
|  || Ro08-9013 ||  7.3716 ||  ||  ||
|-
| [[File:Proflazepam.svg|120px]] || [[Proflazepam]] || 6.8539 / 140nM || 7-chloro-1-(2,3-dihydroxypropyl)-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3050433 3050433] || 52829-30-8
|-
| [[File:Ro22-4683_structure.png|120px]] || Ro22-4683 || 6.5229 / 300nM || 7-nitro-5-(2-fluorophenyl)-1-(t-butyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro15-8852_structure.png|120px]] || Ro15-8852 || 6.1391 / 726nM || 5-(2-chlorophenyl)-4-methyl-7-nitro-4,5-dihydro-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Chlordiazepoxide.svg|120px]] || [[Chlorodiazepoxide]] || 6.4535 / 352nM || 7-chloro-2-methylamino-5-phenyl-3H-benzo[e] [1,4]diazepine-4-oxide || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2712 2712] || 58-25-3
|-
| [[File:Cyprazepam.svg|120px]] || [[Cyprazepam]] ||  || 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-benzo[e] [1,4]diazepin-2-imine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=27452 27452] || 15687-07-7
|-
| [[File:Uldazepam.svg|120px]] || [[Uldazepam]] || 7.6 <sup>†</sup> || 7-chloro-5-(2-chlorophenyl)-N-prop-2-enoxy-3H-benzo[e] [1,4]diazepin-2-amine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=34274 34274] || 28546-58-9
|-
| [[File:Demoxepam.svg|120px]] || [[Demoxepam]] || 6.5086 / 310nM || 7-chloro-1,3-dihydro-5-phenyl-2H-benzo[e] [1,4]diazepin-2-one-4-oxide || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=13756 13756] || 963-39-3
|-
| [[File:Medazepam.svg|120px]] || [[Medazepam]] || IC<sub>50</sub> 870nM || 7-chloro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4041 4041] || 2898-12-6
|-
| [[File:Tuclazepam.svg|120px]] || [[Tuclazepam]] || 7.7 <sup>†</sup> || 7-chloro-5-(2-chlorophenyl)-2-(hydroxymethyl)-1-methyl-2,3-dihydro-1H-benzo[e] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3050405 3050405] ||  51037-88-8
|-
| [[File:Metaclazepam.svg|120px]] || [[Metaclazepam]] ||  || 7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1H-benzo[e] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71272 71272] ||  84031-17-4
|-
| [[File:Sulazepam.svg|120px]] || [[Sulazepam]] || 7.7 <sup>†</sup> || 7-chloro-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-thione || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=17931 17931] || 2898-13-7
|-
| [[File:Tetrazepam.svg|120px]] || [[Tetrazepam]] || 7.4685 / 34nM || 7-chloro-5-(cyclohexen-1-yl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=25215 25215] || 10379-14-3
|-
| [[File:Nortetrazepam.svg|120px]] || [[Nortetrazepam]] || IC<sub>50</sub> 34nM || 7-chloro-5-(cyclohexen-1-yl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=166581 166581] || 10379-11-0
|-
| [[File:Menitrazepam.svg|120px]] || [[Menitrazepam]] ||   || 7-nitro-5-(cyclohexen-1-yl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=189875 189875] || 28781-64-8
|-
| [[File:Ro05-3328_structure.png|120px]] || Ro05-3328 || 7.0605 / 87nM || 7-chloro-5-cyclohexyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Clazolam.svg|120px]] || [[Clazolam]] || 8.1 <sup>†</sup> || 2-chloro-5-methyl-5,9,10,14b-tetrahydroisoquino[2,1-d] [1,4]benzodiazepin-6(7H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24107 24107] || 7492-29-7
|-
| [[File:Bromazepam.svg|120px]] || [[Bromazepam]] ||  7.7447 / 18nM || 7-bromo-5-(pyridin-2-yl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2441 2441] || 1812-30-2
|-
| [[File:Methylbromazepam_structure.png|120px]] || Methylbromazepam ||   || 7-bromo-5-(pyridin-2-yl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=630183 630183] || 1812-33-5
|-
| [[File:diazepam-pyridazine_structure.png|120px]] || Pyridazino-diazepam ||   || 7-chloro-5-(pyridazin-3-yl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  || 
|-
| [[File:nordazepam-pyrazole_structure.png|120px]] || SCHEMBL9684958 ||   || 7-chloro-5-(1H-pyrazol-5-yl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21738192 21738192] || 
|-
| [[File:Compound-6a_structure.png|120px]] || Compound 6a  || 9.5 <sup>†</sup> || 7-chloro-5-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one || 
|-
| [[File:JC-184_structure.png|120px]] || JC-184 ||   || 7-bromo-5-(2-thienyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21065240 21065240] || 
|-
| [[File:BDBM50083903_structure.png|120px]] || BDBM50083903 ||   || 7-chloro-5-(2-furanyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10423506 10423506] || 
|-
|  || Ro05-5605 || 6.5376 ||  ||  ||
|-
|  || Ro11-3129 || 8.1871 || (+)-2-amino-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]propanamide  || [https://pubchem.ncbi.nlm.nih.gov/compound/21413751 21413751]  || 65607-70-7
|-
|  || Ro03-7355 || 6.3768 ||  ||  ||
|-
| [[File:Ro11-4878_structure.png|120px]] || Ro11-4878 || 8.4559 / 3.5nM || 7-chloro-5-(2-fluorophenyl)-3-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Meclonazepam structure.svg|120px]] || [[Meclonazepam]] || 8.9208 / 1.2nM || (3S)-7-nitro-5-(2-chlorophenyl)-3-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3033985 3033985] || 58662-84-3
|-
| [[File:Ro11-6896_structure.png|120px]] || Ro11-6896 || 8.1549 / 7nM || 7-nitro-5-(2-fluorophenyl)-1,3-dimethyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Ro06-7263_structure.png|120px]] || Ro06-7263 || 7.3098 / 49nM || 1,7-dichloro-5-phenyl-3-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Oxazepam.svg|120px]] || [[Oxazepam]] || 7.7447 / 18nM || 7-chloro-3-hydroxy-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4616 4616] || 604-75-1
|-
| [[File:Temazepam.svg|120px]] || [[Temazepam]] || 7.7959 / 16nM || 7-chloro-3-hydroxy-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5391 5391] || 846-50-4
|-
| [[File:Lorazepam.svg|120px]] || [[Lorazepam]]  || 8.4559 / 3.5nM || 7-chloro-3-hydroxy-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3958 3958] || 846-49-1
|-
| [[File:Lormetazepam.svg|120px]] || [[Lormetazepam]]  ||  || 7-chloro-3-hydroxy-5-(2-chlorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=13314 13314] || 848-75-9
|-
| [[File:Flutemazepam structure.svg|120px]] || [[Flutemazepam]]  || 8.1 <sup>†</sup> || 7-chloro-3-hydroxy-5-(2-fluorophenyl)-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=40344 40344] || 52391-89-6
|-
| [[File:Cinolazepam.svg|120px]] || [[Cinolazepam]]  ||  || 7-chloro-3-hydroxy-5-(2-fluorophenyl)-1-(2-cyanoethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3033621 3033621] || 75696-02-5
|-
| [[File:Doxefazepam.svg|120px]] || [[Doxefazepam]]  ||  || 7-chloro-3-hydroxy-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=38668 38668] || 40762-15-0
|-
| [[File:Nifoxipam.svg|120px]] || [[Nifoxipam]]  || 8.5 <sup>†</sup> || 7-nitro-3-hydroxy-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3058221 3058221] || 74723-10-7
|-
| [[File:Nitemazepam.svg|120px]] || [[Nitemazepam]]  ||  || 7-nitro-3-hydroxy-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/12362353 12362353]  ||  40762-03-6
|-
| [[File:3-Hydroxyphenazepam.svg|120px]] || [[3-Hydroxyphenazepam]]  || 8.7 <sup>†</sup> || 7-bromo-3-hydroxy-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=125820 125820] || 70030-11-4
|-
| [[File:Cinazepam.svg|120px]] || [[Cinazepam]]  ||  || 7-bromo-3-succinyloxy-5-(2-chlorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=629281 629281] ||  172986-25-3
|-
| [[File:Pivoxazepam.svg|120px]] || [[Pivoxazepam]]  ||  || 7-chloro-3-pivalyloxy-5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=68722 68722] ||  55299-10-0
|-
| [[File:Camazepam.svg|120px]] || [[Camazepam]] || 6.0458 || 7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl N,N-dimethylcarbamate || [https://pubchem.ncbi.nlm.nih.gov/compound/37367 37367 ] || 36104-80-0
|-
| [[File:Clorazepate.svg|120px]] || [[Clorazepate]] || IC<sub>50</sub> 59nM || 7-chloro-2-oxo-5-phenyl-1H-benzo[e] [1,4]diazepine-3-carboxylic acid || [https://pubchem.ncbi.nlm.nih.gov/compound/2809 2809] || 23887-31-2
|-
| [[File:Nitrazepate structure.svg|120px]] || [[Nitrazepate]] ||  || 7-nitro-2-oxo-5-phenyl-1H-benzo[e] [1,4]diazepine-3-carboxylic acid || [https://pubchem.ncbi.nlm.nih.gov/compound/21740 21740] || 5571-84-6
|-
| [[File:Ethyl carfluzepate.svg|120px]] || [[Ethyl carfluzepate]] || 8.0 <sup>†</sup> || ethyl 7-chloro-5-(2-fluorophenyl)-1-(methylcarbamoyl)-2-oxo-3H-benzo[e] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/68856 68856] || 65400-85-3
|-
| [[File:Ethyl dirazepate.svg|120px]] || [[Ethyl dirazepate]] || 7.5 <sup>†</sup> || ethyl 7-chloro-5-(2-chlorophenyl)-2-oxo-3H-benzo[e] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/208941 208941] || 23980-14-5
|-
| [[File:Ethyl loflazepate.svg|120px]] || [[Ethyl loflazepate]] ||  || ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-3H-benzo[e] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/3299 3299] || 29177-84-2
|-
| [[File:Carburazepam.svg|120px]] || [[Carburazepam]] || 7.9 <sup>†</sup> || 7-chloro-1-methyl-2-oxo-5-phenyl-1,2,3,5-tetrahydro-4H-benzo[e] [1,4]diazepine-4-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/68787 68787] || 59009-93-7
|-
| [[File:Ro20-7078_structure.png|120px]] || Ro20-7078 || 8.2757 / 5.3nM || 3,7-dichloro-5-(2-fluorophenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one ||  ||
|-
| [[File:Clobazam structure.svg|120px]] || [[Clobazam]] ||  6.8861 / 130nM || 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione || [https://pubchem.ncbi.nlm.nih.gov/compound/2789 2789] || 22316-47-8
|-
| [[File:Desmethylclobazam_structure.png|120px]] || Desmethylclobazam || 6.6778 / 210nM || 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione ||  ||
|-
| [[File:Triflubazam.svg|120px]] || [[Triflubazam]] || 8.4 <sup>†</sup> || 7-trifluoromethyl-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione || [https://pubchem.ncbi.nlm.nih.gov/compound/2789 2789] || 22316-47-8
|-
| [[File:Lofendazam.svg|120px]] || [[Lofendazam]] ||   || 7-chloro-5-phenyl-1,3,4,5-tetrahydro-4H-1,5-benzodiazepin-4-one || [https://pubchem.ncbi.nlm.nih.gov/compound/71709 71709] || 29176-29-2
|-
| [[File:Arfendazam.svg|120px]] || [[Arfendazam]] || 8.3 <sup>†</sup> || ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/65803 65803] || 37669-57-1
|-
| [[File:CP-1414S.svg|120px]] || [[CP-1414S]] || 7.9 <sup>†</sup> || 8-nitro-1-phenyl-4-amino-3H-1,5-benzodiazepin-2-one || [https://pubchem.ncbi.nlm.nih.gov/compound/37594 37594] || 36975-99-2
|-
| [[File:Compound-6i_structure.png|120px]] || Compound 6i  || 8.6 <sup>†</sup> || 9-chloro-11-phenyl-6,11-dihydro-5H-pyrimido[4,5-b][1,5]benzodiazepin-5-one || 
|-
| [[File:Oxazolam.svg|120px]] || [[Oxazolam]] ||  || 10-chloro-2-methyl-11b-phenyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d] [1,4]diazepin-6(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/62779 62779] || 24143-17-7
|-
| [[File:Cloxazolam.svg|120px]] || [[Cloxazolam]] ||  || 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/2816 2816] || 24166-13-0
|-
| [[File:Mexazolam.svg|120px]] || [[Mexazolam]] ||  || 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/4177 4177] || 31868-18-5
|-
| [[File:Flutazolam.svg|120px]] || [[Flutazolam]] ||  || 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-[1,3]oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/3398 3398] || 27060-91-9
|-
| [[File:Haloxazolam structure.svg|120px]] || [[Haloxazolam]] ||  || 10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/3563 3563] || 59128-97-1
|-
| [[File:Ketazolam.svg|120px]] || [[Ketazolam]] ||  || 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d] [1,4]benzodiazepine-4,7(6H)-dione || [https://pubchem.ncbi.nlm.nih.gov/compound/33746 33746] || 27223-35-4
|-
| [[File:U-35005_structure.png|120px]] || U-35005 || 8.3665 / 4.3nM || 6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/21680194 21680194] ||
|-
| [[File:4'-Chlorodeschloroalprazolam_structure.png|120px]] || [[4'-Chlorodeschloroalprazolam]] ||   || 6-(4-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/142641556 142641556] || 92262-72-1
|-
| [[File:Estazolam.svg|120px]] || [[Estazolam]]  || 8.0706 / 8.5nM || 8-chloro-6-phenyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3261 3261] || 29975-16-4
|-
| [[File:Alprazolam.svg|120px]] || [[Alprazolam]] || 7.699 / 20nM || 8-chloro-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2118 2118] || 28981-97-7
|-
| [[File:Triazolam.svg|120px]] || [[Triazolam]] || 8.3979 / 4nM || 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5556 5556] || 28911-01-5
|-
| [[File:Alphahydroxytriazolam_structure.png|120px]] || alpha-Hydroxytriazolam || 8.3768 / 4.2nM || 8-chloro-6-(2-chlorophenyl)-1-hydroxymethyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/1963 1963] || 37115-45-0
|-
| [[File:Flualprazolam_structure.svg|120px]] || [[Flualprazolam]] || 8.3 <sup>†</sup> || 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/10359044 10359044] || 28910-91-0
|-
| [[File:Iso-flualprazolam_structure.png|120px]] || Iso-flualprazolam ||  || 8-fluoro-6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine ||  || 
|-
| [[File:Desmethyltriazolam_structure.png|120px]] || Desmethyltriazolam || 8.3 <sup>†</sup> || 8-chloro-6-(2-chlorophenyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/826660 826660] || 42292-42-2
|-
| [[File:Nitrazolam.svg|120px]] || [[Nitrazolam]] || 8.5 <sup>†</sup> || 8-nitro-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20317278 20317278] || 28910-99-8
|-
| [[File:Desmethylnitrazolam_structure.png|120px]] || Desmethylnitrazolam || 8.8 <sup>†</sup> || 8-nitro-6-phenyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20317280 20317280] || 30858-58-3
|-
| [[File:Clonazolam skeletal formula.svg|120px]] || [[Clonazolam]] || 9.5 <sup>†</sup> || 8-nitro-6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/12317881 12317881] || 33887-02-4
|-
| [[File:Flunitrazolam Structural Formula V.1.svg|120px]] || [[Flunitrazolam]] || 8.8 <sup>†</sup> || 8-nitro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=137700379 137700379] || 2243815-18-9
|-
| [[File:Flubromazolam.svg|120px]] || [[Flubromazolam]] (JYI-73) || 8.8 <sup>†</sup> || 8-bromo-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21930924 21930924] || 612526-40-6
|-
| [[File:BDBM50011621_structure.png|120px]] || Fluiodomazolam (BDBM50011621) ||  || 8-iodo-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14851835 14851835] || 
|-
| [[File:SCHEMBL7327294_structure.png|120px]] || Triflumazolam (SCHEMBL7327294) ||  || 8-trifluoromethyl-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=19010444 19010444] || 28910-98-7
|-
| [[File:JYI-70_structure.png|120px]] || JYI-70 ||  || 8-ethynyl-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14851900 14851900] || 
|-
| [[File:XLI-296_structure.png|120px]] || XLI-296 ||  || 8-ethynyl-6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14851901 14851901] || 
|-
| [[File:Clobromazolam_structure.png|120px]] || [[Clobromazolam]] (DM-II-90) || 8.2 <sup>†</sup> || 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/1032830 1032830] || 87213-50-1
|-
| [[File:Bromazolam_structure.png|120px]] || [[Bromazolam]] (XLI-268) || 8.5 <sup>†</sup> || 8-bromo-6-phenyl-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/12562546 12562546] || 71368-80-4
|-
| [[File:Pyrazolam-skeletal.svg|120px]] || [[Pyrazolam]] (SH-I-04) || 8.1 <sup>†</sup> || 8-bromo-6-(pyridin-2-yl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12562545 12562545] || 39243-02-2
|-
| [[File:Pyclazolam_structure.png|120px]] || Pyclazolam || 8.2 <sup>†</sup> || 8-chloro-6-(pyridin-2-yl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20368150 20368150] ||
|-
| [[File:Pynazolam_structure.png|120px]] || [[Pynazolam]] || 9.4 <sup>†</sup> || 8-nitro-6-(pyridin-2-yl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20368157 20368157] || 2034366-97-5
|-
| [[File:Pyeazolam_structure.png|120px]] || [[Pyeazolam]] (SH-TRI-108) || 7.9 <sup>†</sup> || 8-ethynyl-6-(pyridin-2-yl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/71811108 71811108] || 1349115-59-8
|-
| [[File:Adinazolam.svg|120px]] || [[Adinazolam]] || 6.8697 / 135nM || 8-chloro-6-phenyl-1-(N,N-dimethylaminomethyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=37632 37632] || 37115-32-5
|-
| [[File:U-42352_structure.png|120px]] || U-42352  ||   || 8-chloro-6-phenyl-1-(N-methylaminomethyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/119094 119094] || 37115-33-6
|-
| [[File:Fluadinazolam_structure.png|120px]] || [[Fluadinazolam]] || 7.1 <sup>†</sup> || 8-chloro-6-(2-fluorophenyl)-1-(N,N-dimethylaminomethyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=21537253 21537253] || 37391-59-6
|-
| [[File:U-43465F_structure.png|120px]] || U-43465 F || 7.9431 || 8-chloro-1-[2-(dimethylamino) ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/134388 134388]   || 83983-74-8
|-
| [[File:Ro11-5073_structure.png|120px]] || Ro11-5073 || 8.4815 / 3.3nM || (4S)-8-chloro-6-(2-fluorophenyl)-1,4-dimethyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/101637147 101637147] ||
|-
| [[File:Ro11-6679_structure.png|120px]] || Ro11-6679 || 8.3979 / 4nM || 8-nitro-6-(2-fluorophenyl)-1,4-dimethyl-4H-benzo[f] [1,2,4]triazolo[4,3-a] [1,4]diazepine ||  ||
|-
| [[File:Ro17-4582_structure.png|120px]] || Ro17-4582 || 8.4559 / 3.5nM || 4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine ||  ||
|-
| [[File:Etizolam.svg|120px]] || [[Etizolam]] || 8.5086 / 3.1nM ||  2-ethyl-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3307 3307] || 40054-69-1
|-
| [[File:Deschloroetizolam.svg|120px]] || [[Deschloroetizolam]] || 8.5 <sup>†</sup> ||  2-ethyl-4-phenyl-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  ||  [https://pubchem.ncbi.nlm.nih.gov/compound/827322 827322]  || 40054-73-7
|-
| [[File:Desmethyletizolam.svg|120px]] || [[Desmethyletizolam]] ||  ||  2-ethyl-4-(2-chlorophenyl)-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12434325 12434325] || 40054-68-0
|-
| [[File:Fluetizolam_structure.png|120px]] || [[Fluetizolam]] || 8.8 <sup>†</sup> ||  2-ethyl-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=12434320 12434320] || 40054-88-4
|-
| [[File:Nitizolam_structure.png|120px]] || Nitizolam ||  ||  2-nitro-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=70600959 70600959] ||
|-
| [[File:Iprizolam_structure.png|120px]] || Iprotizolam ||  ||  2-isopropyl-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=67727941 67727941] ||
|-
| [[File:Ro11-1465_structure.png|120px]] || [[Clotizolam]] (Ro11-1465) || 8.8539 / 1.4nM || 2-chloro-4-(2-chlorophenyl)-9-methyl-4H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/3041455 3041455]  || 54123-06-7
|-
| [[File:Deschloroclotizolam_structure.png|120px]] || [[Deschloroclotizolam]] ||   || 2-chloro-4-phenyl-9-methyl-4H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/157010678 157010678]  || 1629324-97-5
|-
| [[File:Fluclotizolam_structure.png|120px]] || [[Fluclotizolam]] || 9.1 <sup>†</sup>  || 2-chloro-4-(2-fluorophenyl)-9-methyl-4H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/21317700 21317700]  || 54123-15-8 
|-
| [[File:Difluclotizolam_structure.png|120px]] || Difluclotizolam ||   || 2-chloro-4-(2,6-difluorophenyl)-9-methyl-4H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/21317683 21317683]  || 
|-
| [[File:Brotizolam.svg|120px]] || [[Brotizolam]] || 8.9208 || 2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2451 2451] || 57801-81-7
|-
| [[File:Flubrotizolam_structure.png|120px]] || [[Flubrotizolam]] (LS-152,574) || 9.6 <sup>†</sup> || 2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/3044878 3044878] || 57801-95-3
|-
| [[File:Ro14-1636_structure.png|120px]] || Ro14-1636 || 8.8239 || 2-iodo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14851924 14851924] ||
|-
| [[File:Ciclotizolam structure.svg|120px]] || [[Ciclotizolam]] || 8.0 <sup>†</sup> || 2-bromo-4-(2-chlorophenyl)-9-cyclohexyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71949 71949] || 58765-21-2
|-
|  || Ro11-7800 || 8.5376 / 2.9nM || (2-chloro-4-(2-chlorophenyl)-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-9-yl)methanamine ||  ||
|-
| [[File:Zapizolam.svg|120px]] || [[Zapizolam]] || 8.8 <sup>†</sup> ||  8-chloro-6-(2-chlorophenyl)-4H-pyrido[2,3-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine  || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=68832 68832] || 64098-32-4
|-
| [[File:Rilmazafone metabolite.svg|120px]] || Rilmazolam (LS-188,599) || 7.3 <sup>†</sup> || 8-chloro-6-(2-chlorophenyl)-N,N-dimethyl-4H-1,2,4-triazolo[1,5-a] [1,4]benzodiazepine-2-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/148494 148494] || 50330-59-1
|-
| [[File:Midazolam.svg|120px]] || [[Midazolam]]  || 8.3188 / 4.8nM || 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/4192 4192] || 59467-70-8
|-
| [[File:Alphahydroxymidazolam_structure.png|120px]] || alpha-Hydroxymidazolam || 8.3468 / 4.5nM || 8-chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5-a] [1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/107917 107917] || 59468-90-5
|-
| [[File:Ro22-0284_structure.png|120px]] || Ro22-0284  ||  || 8-chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4-hydroxy-4H-imidazo[1,5-a] [1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/10316307 10316307] || 64740-68-7
|-
| [[File:Climazolam.svg|120px]] || [[Climazolam]]  || 8.1 <sup>†</sup> || 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine || [https://pubchem.ncbi.nlm.nih.gov/compound/68790 68790] || 59467-77-5
|-
| [[File:Remimazolam.svg|120px]] || [[Remimazolam]]  || 8.3 <sup>†</sup> || methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]propanoate || [https://pubchem.ncbi.nlm.nih.gov/compound/9824461 9824461] || 308242-62-8
|-
| [[File:Ro15-8670_structure.png|120px]] || Ro15-8670 || 7.8239 / 15nM || ethyl 8-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/14907889 14907889] ||
|-
| [[File:JYI-32_structure.png|120px]] || JYI-32 ||   || ethyl 8-bromo-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/21930922 21930922] ||
|-
| [[File:JY-XHE-057_structure.png|120px]] || JY-XHE-057 ||   || ethyl 8-ethynyl-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/21065283 21065283] ||
|-
| [[File:Ro16-0529_structure.png|120px]] || Ro16-0529 || 7.8539 / 14nM || tert-butyl 7-chloro-6-phenyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate ||  ||
|-
| [[File:Ro21-5205_structure.png|120px]] || Ro21-5205 || 8.1308 / 7.4nM || methyl 8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/12801973 12801973] ||
|-
| [[File:SH-053-R-CH3-2′F.svg|120px]] || [[SH-053-R-CH3-2'F]] || 7.9 <sup>†</sup>  || ethyl (4R)-8-ethynyl-6-(2-fluorophenyl)-4-methyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11574585 11574585] || 872874-14-1
|-
| [[File:HZ-166_structure.png|120px]] || HZ-166 ||   || ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10309028 10309028] || 612527-56-7
|-
| [[File:MP-III-022_structure.png|120px]] || MP-III-022 || 9.1 <sup>†</sup> || (4R)-8-ethynyl-6-(2-fluorophenyl)-N,4-dimethyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/130439777 130439777] || 
|-
| [[File:GL-II-73_structure.png|120px]] || [[GL-II-73]] ||   || (4R)-8-ethynyl-6-(2-fluorophenyl)-N,N,4-trimethyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/130439778 130439778] || 
|-
| [[File:YT-III-31_structure.png|120px]] || YT-III-31 ||   || 8-ethynyl-6-phenyl-N-methyl-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/49848318 49848318] || 
|-
|  || Ro22-1892 || 7.9208 / 12nM || 8-chloro-6-(2-fluorophenyl)-3-(isopropoxycarbonyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine 5-oxide ||  ||
|-
| [[File:Ro22-0992_structure.png|120px]] || Ro22-0992 || 7.8861 / 13nM || 8-chloro-6-(2-chlorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylic acid ||  ||
|-
| [[File:Ro21-8137_structure.png|120px]] || Ro21-8137 || 8.4559 / 3.5nM || 8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide ||  ||
|-
| [[File:Ro21-8384_structure.png|120px]] || Ro21-8384 || 8.4202 || 8-chloro-6-(2-chlorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/162997 162997] || 63176-94-3
|-
| [[File:Imidazenil.svg|120px]] || [[Imidazenil]] || 8.8 <sup>†</sup> || 8-fluoro-6-(2-bromophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/119194 119194] || 151271-08-8
|-
| [[File:Ro23-0364_structure.png|120px]] || Ro23-0364 ||  || 6-(2-chlorophenyl)-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide || [https://pubchem.ncbi.nlm.nih.gov/compound/194998 194998] || 113066-25-4
|-
| [[File:Ro21-8482_structure.png|120px]] || Ro21-8482 || 7.585 / 26nM || 8-chloro-6-(2-chlorophenyl)-1-[(dimethylamino)methyl]-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide ||  ||
|-
| [[File:Loprazolam.svg|120px]] || [[Loprazolam]] || 8.2007 || (2Z)-6-(2-chlorophenyl)-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-2,4-dihydro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one ||  [https://pubchem.ncbi.nlm.nih.gov/compound/3033860 3033860] || 61197-73-7
|-
| [[File:Fluloprazolam_structure.png|120px]] || Fluloprazolam || 8.0 <sup>†</sup> || (2Z)-6-(2-fluorophenyl)-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-2,4-dihydro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one ||  [https://pubchem.ncbi.nlm.nih.gov/compound/12371485 12371485] ||
|-
| [[File:PS-I-35_structure.png|120px]] || PS-I-35 ||   || (2Z)-6-phenyl-2-[(4-methyl-1-piperazinyl)methylene]-8-bromo-2,4-dihydro-1H-imidazo[1,2-a] [1,4]benzodiazepin-1-one ||  [https://pubchem.ncbi.nlm.nih.gov/compound/72660859 72660859] ||
|-
|  || Ro14-1359 || 7.1549 / 70nM || 7-chloro-5-(2-fluorophenyl)-1H-benzo[b]azepin-2(3H)-one ||  ||
|-
|  || Ro15-8867 || 7.6021 / 25nM || 7-nitro-5-(2-chlorophenyl)-1H-benzo[b]azepin-2(3H)-one ||  ||
|-
| [[File:Ro14-7187_structure.png|120px]] || Ro14-7187 || 6.3872 / 410nM || 1-methyl-6-phenyl-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine || [https://pubchem.ncbi.nlm.nih.gov/compound/85687871 85687871]  ||
|-
|  || Ro13-9868 || 7.3768 / 42nM || 8-chloro-1-methyl-6-phenyl-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine ||  ||
|-
| [[File:Ro14-5921_structure.png|120px]] || Ro14-5921 || 7.7212 / 19nM || 8-chloro-6-(2-fluorophenyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20449965 20449965] ||
|-
| [[File:Ro14-0304_structure.png|120px]] || Ro14-0304 || 8.1871 / 6.5nM || 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20449964 20449964] ||
|-
|  || Ro14-2652 || 8.2518 / 5.6nM || (8-chloro-6-(2-fluorophenyl)-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepin-1-yl)methanamine ||  ||
|-
| [[File:Ro15-9270_structure.png|120px]] || Ro15-9270 || 8.301 / 5nM || 6-(2-chlorophenyl)-1-methyl-8-nitro-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine || [https://pubchem.ncbi.nlm.nih.gov/compound/20450010 20450010] ||
|-
|  || Ro14-0609 || 7.6126 / 24.4nM || 8-chloro-6-(2-fluorophenyl)-5,6-dihydro-4H-benzo[f] [1,2,4]triazolo[4,3-a]azepine ||  ||
|-
|  || Ro15-2201 || 8.8239 / 1.5nM || methyl 6-phenyl-4H-benzo[f]imidazo[1,5-a]azepine-3-carboxylate ||  ||
|-
|  || Ro15-0791 || 8.6021 / 2.5nM || ethyl 6-phenyl-4H-benzo[f]imidazo[1,5-a]azepine-3-carboxylate ||  ||
|-
|  || Ro15-2200 || 8.3768 / 4.2nM || ethyl 6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a]azepine-3-carboxylate ||  ||
|-
|  || Ro14-3929 || 7.7959 / 16nM || ethyl 8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a]azepine-3-carboxylate ||  ||
|-
|  || Ro14-3930 || 7.8239 / 15nM || 8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a]azepine-3-carboxamide ||  ||
|-
|  || Ro14-5568 || 6.6383 / 230nM || 8-chloro-6-(2-fluorophenyl)-4H-benzo[f]imidazo[1,5-a]azepine ||  ||
|-
| [[File:Ro22-1274_structure.png|120px]] || Ro22-1274 || 7.1249 / 75nM || 8-chloro-1-(2-fluorophenyl)-3H-benzo[c]azepine || [https://pubchem.ncbi.nlm.nih.gov/compound/13271760 13271760] || 89376-31-8
|-
|  || Ro22-1251 || 7.9586 / 11nM || 9-chloro-2-methyl-7-phenyl-5H-benzo[c]pyrimido[4,5-e]azepine ||  ||
|-
|  || Ro22-1366 || 8.3979 / 4nM || 9-chloro-7-(2-fluorophenyl)-2-methyl-5H-benzo[c]pyrimido[4,5-e]azepine ||  ||
|-
|  || Ro22-2038 || 8.5528 / 2.8nM || 9-chloro-7-(2-fluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-amine ||  ||
|-
|  || Ro22-3245 || 8.5528 / 2.8nM || 9-chloro-7-(2-chlorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepine ||  ||
|-
|  || Ro22-3148 || 6.3768 / 420nM || 6-phenyl-2,4-dihydrobenzo[c] [1,2,3]triazolo[4,5-e]azepine ||  ||
|-
|  || Ro22-3147 || 8.284 / 5.2nM || 6-(2-chlorophenyl)-2,4-dihydrobenzo[c] [1,2,3]triazolo[4,5-e]azepine ||  ||
|-
|  || Ro22-0780 || 7.9586 / 11nM || 8-chloro-6-phenyl-2,4-dihydrobenzo[c] [1,2,3]triazolo[4,5-e]azepine ||  ||
|-
|  || Ro22-2466 || 8.7212 / 1.9nM || 8-chloro-6-(2-fluorophenyl)-2,4-dihydrobenzo[c] [1,2,3]triazolo[4,5-e]azepine ||  ||
|-
|  || Ro22-2468 || 8.6021 ||  ||  ||
|-
| [[File:Ro22-8515_structure.png|120px]] || Ro22-8515 ||   || 8-chloro-6-(2-chlorophenyl)-1,4-dihydropyrrolo[3,4-d] [2]benzazepin-3(2H)-one || [https://pubchem.ncbi.nlm.nih.gov/compound/145981 145981] ||
|-
| [[File:Ro14-5974_structure.png|120px]] || Ro14-5974 || 8.1938 / 6.4nM || (S)-ethyl 9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compounds/10041121 10041121] || 88552-32-3
|-
| [[File:Ro15-4941_structure.png|120px]] || Ro15-4941 || 8.7696 / 1.7nM || (S)-ethyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
| [[File:Ro14-5975_structure.png|120px]] || Ro14-5975 || 7.2076 / 62nM || (S)-ethyl 7-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
| [[File:Ro16-3607_structure.png|120px]] || Ro16-3607 || 7.3372 / 46nM || (S)-tert-butyl 8-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
| [[File:Ro16-6624_structure.png|120px]] || Ro16-6624 || 8 / 10nM || (S)-tert-butyl 8-ethyl-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
| [[File:Ro16-3774_structure.png|120px]] || Ro16-3774 || 8.4949 / 3.2nM || (S)-tert-butyl 8-methyl-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-0071 || 8.4949 / 3.2nM || (S)-tert-butyl 9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-5824 || 8.4685 / 3.4nM || (S)-tert-butyl 8-(methylthio)-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-8912 || 8.2076 / 6.2nM || (S)-tert-butyl 8-fluoro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-4261 || 8.1135 / 7.7nM || (S)-tert-butyl 7-fluoro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-0075 || 8.6021 ||  ||  ||
|-
|  || Ro16-6127 || 8.5086 / 3.1nM || (S)-tert-butyl 8-chloro-7-fluoro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-3058 || 7.0458 ||  ||  ||
|-
| [[File:Bretazenil.svg|120px]] || [[Bretazenil]] || 8.6576 || (S)-tert-butyl 8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c] [1,4]benzodiazepine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=107926 107926] || 84379-13-5
|-
| [[File:EVT-201.svg|120px]] || [[EVT-201]] ||  || 7-chloro-3-(5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl)-5-methyl-4,5-dihydro-6H-imidazo[1,5-a] [1,4]benzodiazepin-6-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9885841 9885841] || 308239-86-3
|-
| [[File:FG-8205.svg|120px]] || [[FG-8205]] ||  || 7-chloro-5-methyl-3-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)-4H-imidazo[1,5-a] [1,4]benzodiazepin-6-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=129710 129710] || 122384-14-9
|-
| [[File:L-655,708.svg|120px]] || [[L-655,708]] ||  || ethyl (13aS)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c] [1,4]benzodiazepine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311203 5311203] || 130477-52-0
|-
| [[File:PWZ-029.svg|120px]] || [[PWZ-029]] ||  || 8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepin-6-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9971547 9971547] ||
|-
| [[File:Ro48-6791.svg|120px]] || [[Ro48-6791]] ||  || 8-fluoro-5-methyl-3-(5-[(dipropylamino)methyl]-1,2,4-oxadiazol-3-yl)-4H-imidazo[1,5-a] [1,4]benzodiazepin-6-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9953485 9953485] || 172407-17-9
|-
| [[File:Ro48-8684.svg|120px]] || [[Ro48-8684]] ||  || 8-fluoro-5-methyl-3-(5-[(dipropylamino)methyl]-1,3-oxazol-2-yl)-4H-imidazo[1,5-a] [1,4]benzodiazepin-6-one || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9866317 9866317] ||
|-
| [[File:Ro4882224_structure.png|120px]] || Ro4882224 ||  || 3,10-dichloro-9H-benzo[f]imidazo[1,5-a] [1,2,4]triazolo[1,5-d] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11673720 11673720] ||
|-
| [[File:Ro4938581.svg|120px]] || [[Ro4938581]] ||  || 3-bromo-10-(difluoromethyl)-9H-benzo[f]imidazo[1,5-a] [1,2,4]triazolo[1,5-d] [1,4]diazepine || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11624499 11624499] || 883093-10-5
|-
|  || Ro16-6605 || 8.6778 ||  ||  ||
|-
|  || Ro16-6048 || 8.4815 / 3.3nM || (S)-tert-butyl 9-oxo-8-(trifluoromethyl)-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-6950 || 8.5528 / 2.8nM || (S)-tert-butyl 8-nitro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-4019 || 8.8539 / 1.4nM || (S)-propyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-3031 || 8.6021 / 2.5nM || (S)-isopropyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-9906 || 8.7696 / 1.7nM || (S)-allyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-7081 || 8.585 ||  ||  ||
|-
|  || Ro16-7082 || 8.2007 / 6.3nM || (S)-isobutyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-7083 || 8.5376 / 2.9nM || (13aS)-sec-butyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-9918 || 8.6383 / 2.3nM || (S)-cyclopropylmethyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-4020 || 8.585 ||  ||  ||
|-
|  || Ro16-6654 || 8.3979 / 4nM || (S)-cyclohexyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro17-3206 || 8.4685 ||  ||  ||
|-
|  || Ro17-3207 || 8.284 ||  ||  ||
|-
|  || Ro16-4021 || 8.8239 ||  ||  ||
|-
|  || Ro17-1302 || 8.2757 / 5.3nM || (S)-phenyl 8-chloro-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro15-2427 || IC<sub>50</sub> >1000nM || 5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxamide ||  ||
|-
| [[File:Ro14-7437_structure.png|120px]] || Ro14-7437 || 8.5229 / 3nM || ethyl 5-methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compounds/127597 127597] || 83210-63-3
|-
| [[File:Sarmazenil.svg|120px]] || [[Sarmazenil]] (Ro15-3505) || 8.5686 / 2.7nM || ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate ||[https://pubchem.ncbi.nlm.nih.gov/compound/71231 71231] || 78771-13-8 
|-
| [[File:Ro15-1310_structure.png|120px]] || Ro15-1310 || 8.1675 / 6.8nM || ethyl 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compounds/114888 114888] || 78756-33-9
|-
| [[File:Ro15-1746_structure.png|120px]] || Ro15-1746 || IC<sub>50</sub> >1000nM || ethyl 9-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate ||  ||
|-
| [[File:Ro15-3237_structure.png|120px]] || Ro15-3237 || IC<sub>50</sub> >1000nM || ethyl 10-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate ||  ||
|-
|  || Ro15-5623 || 8.699 ||  ||  ||
|-
| [[File:Flumazenil.svg|120px]] || [[Flumazenil]] || 8.6021 || ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/3373 3373] || 78755-81-4
|-
| [[File:Ro15-4513.svg|120px]] || [[Ro15-4513]]  ||  ||  ethyl 8-azido-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5081 5081] || 91917-65-6
|-
| [[File:RY-031_structure.png|120px]] || RY-031  ||  ||  ethyl 8-ethyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10245056 10245056] || 
|-
| [[File:TG-4-29_structure.png|120px]] || TG-4-29  ||  ||  ethyl 8-vinyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10591116 10591116] || 
|-
| [[File:RY-080_structure.png|120px]] || RY-080  ||  ||  ethyl 8-ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311418 5311418] || 
|-
| [[File:YT-II-76_structure.png|120px]] || YT-II-76  ||  ||  ethyl 8-cyclopropyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46214569 46214569] ||
|-
| [[File:SVO-8-14_structure.png|120px]] || SVO-8-14  ||  ||  ethyl 8-allyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15316982 15316982] ||
|-
| [[File:SVO-8-30_structure.png|120px]] || SVO-8-30  ||  ||  ethyl 8-(furan-2-yl)-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15316986 15316986] || 
|-
| [[File:SVO-8-67_structure.png|120px]] || SVO-8-67  ||  ||  ethyl 8-phenyl-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15316984 15316984] || 
|-
| [[File:TG-4-39_structure.png|120px]] || TG-4-39  ||  ||  ethyl 8-(thiophen-2-yl)-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15316985 15316985] || 
|-
| [[File:CD-214_structure.png|120px]] || CD-214  ||  ||  cyclopropyl 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=101652266 101652266] || 
|-
| [[File:DM-139_structure.png|120px]] || DM-139  ||  ||  t-butyl 8-(pyrrolidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10547937 10547937] || 
|-
| [[File:DM-146_structure.png|120px]] || DM-146  ||  ||  t-butyl 8-(piperidin-1-yl)-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10834569 10834569] || 
|-
| [[File:DM-173_structure.png|120px]] || DM-173  ||  ||  t-butyl 8-(dimethylamino)-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10808192 10808192] || 
|-
| [[File:DM-215_structure.png|120px]] || DM-215  ||  ||  t-butyl 8-methoxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10807310 10807310] || 
|-
| [[File:Ro19-4603_structure.png|120px]] || Ro19-4603 ||  || t-butyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/127382 127382] || 99632-94-7
|-
| [[File:Iomazenil.svg|120px]] || [[Iomazenil]] ||  || ethyl 7-iodo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a] [1,4]diazepine-3-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/10251042 10251042] || 127985-21-1
|-
|  || Ro17-9741 || 8.6198 / 2.4nM || (S)-methyl 8-chloro-9-oxo-9,11,12,12a-tetrahydroazeto[1,2-a]benzo[e]imidazo[5,1-c] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-0858 || 8.8861 || ethyl 8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[1,2-a]benzo[e]imidazo[5,1-c] [1,4]diazepine-1-carboxylate ||  ||
|-
|  || Ro16-0153  || 8.2757 ||  tert-butyl 8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]benzo[e]imidazo[1,5-a] [1,4]diazepine-1-carboxylate ||  ||
|-
| [[File:Ro17-1812_structure.png|120px]] || Ro17-1812 || 8.8861 || (S)-cyclopropylmethyl 8-chloro-9-oxo-9,11,12,12a-tetrahydroazeto[1,2-a]benzo[e]imidazo[5,1-c] [1,4]diazepine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/compound/146197 146197] || 90450-01-4
|-
|  || Ro17-3211 || 8.62 ||  ||  ||
|-
|  || Ro17-3401 || 9.0458 ||  ||  ||
|-
|  || Ro17-3620 || 8.2924 ||  ||  ||
|-
|  || Ro16-9351 || 8.4318 ||  ||  ||
|-
|  || Ro16-9905 || 8.9208 ||  ||  ||
|-
|  || Ro17-1338 || 9 ||  ||  ||
|-
| [[File:Zopiclone.svg|120px]] || [[Zopiclone]] || 7.5086 || 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate || [https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5735 5735] || 43200-80-2
|-
| [[File:Suriclone.svg|120px]] || [[Suriclone]] || 8.6778 || [6-(7-chloro- 1,8-naphthyridin-2-yl)- 5-oxo- 3,7-dihydro- 2H-[1,4]dithiino[2,3-c]pyrrol- 7-yl]4-methylpiperazine- 1-carboxylate ||  [https://pubchem.ncbi.nlm.nih.gov/compound/40903 40903] || 53813-83-5
|-
| [[File:CL-218,872.svg|120px]] || [[CL-218,872]] || 6.9208 || 3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-f]pyridazine || [https://pubchem.ncbi.nlm.nih.gov/compound/107950 107950] || 66548-69-4
|-
| [[File:GBLD-345_structure.png|120px]] || [[GBLD-345]] || 9 || 2-(4-aminophenyl)-3-methoxy-N-[(3-methoxyphenyl)methyl]imidazo[2,1-f]pyridazin-6-amine || [https://pubchem.ncbi.nlm.nih.gov/compound/4602899 4602899] || 122479-08-7
|-
|}
|}

== See also ==
* [[Benzodiazepine]]
* [[Benzodiazepine dependence]]
* [[Benzodiazepine withdrawal syndrome]]

== References ==
{{Reflist}}

== Further reading ==
{{refbegin}}
* {{cite book | vauthors = Gitlow S |title=Substance Use Disorders: A Practical Guide |url=https://books.google.com/books?id=rbrSdWVerBUC |edition=2nd |date=1 October 2006 |publisher=Lippincott Williams and Wilkins |location=USA |isbn=978-0-7817-6998-3 |page=110}}
* {{cite book | vauthors = Galanter M, Kleber HD |title=The American Psychiatric Publishing Textbook of Substance Abuse Treatment |url=https://books.google.com/books?id=6wdJgejlQzYC |edition=4th |date=1 July 2008 |publisher=American Psychiatric Publishing Inc |location=United States of America |isbn=978-1-58562-276-4 |page=216 }}
{{refend}}

{{Benzodiazepines}}

[[Category:Benzodiazepines|*]]
[[Category:Comparison of psychoactive substances]]