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Lymphangitis carcinomatosa is inflammation of the lymph vessels (lymphangitis) caused by a malignancy. Breast, lung, stomach, pancreas, and prostate cancers are the most common tumors that result in lymphangitis. Lymphangistis carcinomatosa may be caused by the following malignancies as suggested by the mnemonic:"Certain Cancers Spread By Plugging The Lymphatics" C-Cervical cancer,Cancer-Colon cancer,Spread-stomach cancer,By-Breast cancer/Bronchiogenic carcinoma,Plugging-Pancreas,The-Thyroid,Lymphatics-Larynx. Lymphangitis carcinomatosa was first described by pathologist Gabriel Andral in 1829 in a patient with uterine cancer.Lymphangitis carcinomatosa may show the presence of Kerley B lines on chest xray
Lymphangitis carcinomatosis most often affects people 40–49 years of age.
In most cases, lymphangitis carcinomatosis is caused by the dissemination of a tumor with its cells along the lymphatics. However, in about 20 percent of cases, the inflammation of the lymphatic tubules (lymphangitis) is caused by a tumor that blocks the drainage of the lymph duct. In the lung, this is often caused by a centrally located mass, near the hilum of the lung that blocks lymphatic drainage.
Previously, the finding of lymphangitis carcinomatosis meant about a six-month life expectancy. However, improved treatment has improved survival in patients with lymphangitis carcinomatosis, with patients often surviving three or more years with treatment.
- Bruce DM, Heys SD, Eremin O (February 1996). "Lymphangitis carcinomatosa: a literature review.". J R Coll Surg Edinb. 41 (1): 7–13. PMID 8930034.
- McKean, Sylvia; Jacobson, FL (2012). Principles and practice of hospital medicine: Chapter 108: Advanced Cardiothoracic Imaging. New York: McGraw-Hill. ISBN 9780071603898.
- Doyle L. (August 1989). "Gabriel Andral (1797–1876) and the first reports of lymphangitis carcinomatosa". J R Soc Med. 82 (8): 491–3. PMC . PMID 2674433.
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