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Lynda Bonewald

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Lynda Faye Bonewald
Alma materUniversity of Texas at Austin, Medical University of South Carolina
Scientific career
FieldsBone, Musculoskeletal system
InstitutionsUniversity of Missouri–Kansas City, Indiana University School of Medicine

Lynda Bonewald is a professor of anatomy, cell biology, physiology, and orthopaedic surgery and the founding director of the Indiana Center for Musculoskeletal Health (ICMH) at the Indiana University School of Medicine.[1] She studies bone and the musculoskeletal system. She has served as president of the American Society for Bone and Mineral Research (ASBMR, 2012-2013)[2] and the Association of Biomolecular Resource Facilities (1999-2000).[3]

Early life and education

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Bonewald graduated from the University of Texas at Austin[2] and earned a Ph.D. in Immunology/Microbiology from the Medical University of South Carolina[4] in 1984.[5]

Career

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Bonewald was a post-doctoral fellow at the Ralph H. Johnson Veterans Affairs Medical Center in Charleston, South Carolina[5] where she worked with Makio Ogawa on growth factors for hematopoietic stem cells.[2]

Bonewald joined the University of Texas Health Science Center at San Antonio in 1986 as an assistant professor, working with Gregory Robert Mundy.[2]

In 2001, she joined the University of Missouri–Kansas City (UMKC), becoming the Lefkowitz Professor of Oral Biology and the director of the Bone Biology Research Program at UMKC's School of Dentistry.[6][7] In 2009, she and her collaborators received funding from the National Institutes of Health through a National Institute of Arthritis and Musculoskeletal and Skin Diseases ‘Grand Opportunity’ grant.[8] In 2009 Bonewald also became director of the UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues[6][5] and took on the newly-created position of Interim Vice Chancellor for Research at UMKC.[9]

In 2015, as Vice Chancellor for Translational and Clinical Research at UMKC,[10] Bonewald became the founding director of the Kansas City Consortium on Musculoskeletal Diseases (KCMD). Leadership of the consortium rotated between its partners, UMKC, the University of Kansas Medical Center and the Kansas City University of Medicine and Biosciences.[11]

As of 2016, Bonewald was appointed as the founding director of the Indiana Center for Musculoskeletal Health (ICMH) at the Indiana University School of Medicine.[5]

Bonewald served as president of the American Society for Bone and Mineral Research (ASBMR) for 2012-2013.[2][12] She was president of the Association of Biomolecular Resource Facilities for 1999-2000.[3] She has served on the council of the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the NIH.[6]

She is a member of the American Association for Dental Research (AADR), and the International Association for Dental Research (IADR).[12] She has been chair of the Board of Scientific Counselors for the National Institute of Dental and Craniofacial Research (NIDCR).[9]

Research

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Bonewald is a leading bone researcher working to better understand the musculoskeletal system, the effects of aging, and the treatment of musculoskeletal diseases such as osteoporosis and sarcopenia.[12] Despite being told that she would waste her time, she focused on a largely ignored topic that she found interesting.[13][1]

“I kept looking at these beautiful cells that were located inside this hard bone tissue, and I started asking people, ‘What do these cells do?’ ... One colleague said, ‘They don’t do anything,’ and another said, ‘They’re too hard to study. It will ruin your career.’” [1]

Bonewald went on to make important discoveries relating to astrocytes and osteocytes.[4][13] Astrocytes are cells in the brain and spinal cord. Osteocytes are cells, embedded in the mineralized matrix of bone structure, which are important in muscle-bone interactions and communications between them.[14][15][16] Bonewald discovered that osteocytes and muscle cells send signals to each other that influence growth and deterioration of both bone and muscle. Bonewald now studies endocrine crosstalk between bone and muscle and how this relates to aging. Her work has enabled researchers to better understand age-related bone and muscle loss and suggests possible novel treatments.[12][13][17]

Bonewald has contributed to the advancement of the field with more than 200 publications, 42 reviews, and four commentaries.[4] She has developed tools which are used globally by researches to study osteocyte biology and function. She holds nine patents.[4]

Awards

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References

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  1. ^ a b c d Gates, Laura (21 October 2020). "IU School of Medicine's Bonewald blazes trail for researchers in musculoskeletal field". Indiana University School of Medicine. Retrieved 9 March 2022.
  2. ^ a b c d e Goetz, Amy (October 12, 2012). "Lynda F. Bonewald, Ph.D., Takes Office as President of the American Society for Bone and Mineral Research". American Society for Bone and Mineral Research. Retrieved 9 March 2022.
  3. ^ a b "Past Executive Board Members". Association of Biomolecular Resources Facilities. Retrieved 9 March 2022.
  4. ^ a b c d e "Lynda Faye Bonewald: University Honors and Awards: Indiana University". Indiana University. Retrieved 9 March 2022.
  5. ^ a b c d Twigg, Tara (April 7, 2016). "IU Musculoskeletal Health Center Appoints Director". Inside INdiana Business. Retrieved 9 March 2022.
  6. ^ a b c "Bone research leader appointed first director of IU musculoskeletal health center". Indiana University Newsroom. 15 March 2016. Retrieved 9 March 2022.
  7. ^ a b "UMKC bone scientist receives national award | University of Missouri System". UMKC Today Archives. July 14, 2015. Retrieved 9 March 2022.
  8. ^ "Bone biology and muscle biology researchers awarded $1.1 million 'Grand Opportunity' grant – Research news from the University of Missouri-Kansas City". UExplore. October 10, 2009. Retrieved 9 March 2022.
  9. ^ a b c "Dr. Lynda Bonewald appointed Interim Vice Chancellor for Research". Explorer. No. Winter. 2009. p. 7. Retrieved 9 March 2022.
  10. ^ a b "UMKC researcher to be honored for bone disease work". Midtown KC Post. 14 July 2015. Retrieved 9 March 2022.
  11. ^ Kansas City University of Medicine and Biosciences (KCUMB) (February 26, 2015). "Three Kansas City Health Sciences Schools Partner in Musculoskeletal Disease Research Consortium". PRNewswire. Retrieved 9 March 2022.
  12. ^ a b c d "Trail Blazer: Dr. Lynda Bonewald on new muscle-bone research models and breakthroughs". Aging in Motion. 25 March 2013. Retrieved 9 March 2022.
  13. ^ a b c Dance, Amber (23 February 2022). "Fun facts about bones: More than just scaffolding". Knowable Magazine. doi:10.1146/knowable-022222-1. Retrieved 9 March 2022.
  14. ^ Box, Terri (16 December 2019). "Indiana University Leaders, Faculty Elected 2019 American Association for the Advancement of Science". WBIW. Retrieved 9 March 2022.
  15. ^ Bonewald, L.F. (2005). "Generation and function of osteocyte dendritic processes" (PDF). J Musculoskelet Neuronal Interact. 5 (4): 321–324. PMID 16340122. Retrieved 9 March 2022.
  16. ^ Bonewald, Lynda F.; Johnson, Mark L. (1 April 2008). "Osteocytes, mechanosensing and Wnt signaling". Bone. 42 (4): 606–615. doi:10.1016/j.bone.2007.12.224. ISSN 8756-3282. PMC 2349095. PMID 18280232. Retrieved 9 March 2022.
  17. ^ Robling, Alexander G.; Bonewald, Lynda F. (10 February 2020). "The Osteocyte: New Insights". Annual Review of Physiology. 82 (1): 485–506. doi:10.1146/annurev-physiol-021119-034332. ISSN 0066-4278. PMC 8274561. PMID 32040934. Retrieved 9 March 2022.
  18. ^ "Five Damon Runyon Alumni Elected as 2019 AAAS Fellows". Damon Runyon Cancer Research Foundation. December 3, 2019. Retrieved 9 March 2022.
  19. ^ Burr, David B. (2006). "The 36th International Sun Valley Workshop on Skeletal Tissue Biology: Foreword" (PDF). J Musculoskelet Neuronal Interact. 6 (4): 314–31. Retrieved 9 March 2022.
  20. ^ Cohen, Adam D. (26 November 2019). "AAAS Announces Leading Scientists Elected as 2019 Fellows". American Association for the Advancement of Science. Retrieved 9 March 2022.
  21. ^ "2021 Class of Fellows". American Society for Bone and Mineral Research. 22 June 2021. Retrieved 9 March 2022.
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