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Lynne E. Maquat

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Lynne Maquat
Born
Lynne Elizabeth Maquat
NationalityAmerican
Alma materUniversity of Wisconsin–Madison
University of Connecticut
Known forRNA biology in human diseases
AwardsAlbany Medical Center Prize in Medicine and Biomedical Research (2024)
Dr. Paul Janssen Award for Biomedical Research (2024)
Gruber Prize in Genetics (2023)
Wolf Prize in Medicine (2021)
FASEB Excellence in Science Award (2018)
Wiley Prize (2018)
Gairdner Foundation International Award (2015)
William C. Rose Award (2014)
Member of the National Academy of Sciences (2011)
Scientific career
FieldsBiochemistry
Molecular biology
Cell biology
InstitutionsUniversity of Rochester
Doctoral advisorWilliam S. Reznikoff[citation needed]
Websitewww.urmc.rochester.edu/labs/maquat-lab

Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is known for her work in describing the process of nonsense-mediated decay. She is an elected member of the American Academy of Arts and Sciences,[1] the National Academy of Sciences[2] and the National Academy of Medicine.[3] She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and oncology at the University of Rochester Medical Center.[4]

Education

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Maquat graduated magna cum laude with a Bachelor of Science degree in biology from the University of Connecticut in 1974. She received her PhD in biochemistry from the University of Wisconsin-Madison in 1979.[5]

Career and research

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Maquat did postdoctoral research at the McArdle Laboratory for Cancer Research in Madison, Wisconsin. She then had a brief stint at Roswell Park Comprehensive Cancer Center in Buffalo, New York before settling at the University of Rochester in Rochester, New York, where she now holds an endowed chair. Her research is focused on mRNA decay and the molecular basis of human disease. Her research Specifically, she was the first to describe nonsense-mediated mRNA decay, work that enabled the discovery of the exon junction complex as a critical quality-control mechanism in the cell. She also described Staufen-mediated mRNA decay, a competitive process to NMD, and microRNA degradation. Her research began with beta thalassemia as a model and expanded to other hemoglobinopathies. She has also studied cell death in breast cancer cells exposed to chemotherapy, and cellular differentiation in muscle cells. Maquat also founded the Graduate Women in Science program at the University of Rochester Medical School, which provides mentoring and support to women seeking graduate education in the sciences.[6][7][8]

Elected fellowships/memberships

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Awards and honors

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References

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  1. ^ "Membership". www.amacad.org. Retrieved 2017-09-22.
  2. ^ "Lynne Maquat". National Academy of Sciences Online. Retrieved 2017-09-22.
  3. ^ "National Academy of Medicine Elects 80 New Members - National Academy of Medicine". National Academy of Medicine. 2017-10-16. Retrieved 2018-01-02.
  4. ^ "Lynne Elizabeth Maquat, Ph.D. - University of Rochester Medical Center". www.urmc.rochester.edu. Retrieved 2017-09-22.
  5. ^ Emily Boynton; Christine Roth (26 April 2018). "No Boundaries: The Spirit and Science of Lynne Maquat". Rochester Medicine Magazine. University of Rochester.
  6. ^ "Center for RNA Biology: From Genome to Therapeutics - University of Rochester Medical Center". www.urmc.rochester.edu. Retrieved 2017-09-22.
  7. ^ "Graduate Women In Science (GWIS) - Students - Education - University of Rochester Medical Center". www.urmc.rochester.edu. Retrieved 2017-09-22.
  8. ^ "Lynne Elizabeth Maquat, Ph.D. | UR Medicine". University of Rochester Medical Center. Retrieved 2024-10-19.
  9. ^ "Lynne Maquat wins 2014 Athena award". Rochester Democrat and Chronicle. Retrieved 2018-10-23.
  10. ^ "Lynne Maquat wins 2014 Athena award". ROC. Retrieved 2018-10-23.
  11. ^ "2014 ASBMB Annual Awards: William C. Rose Award". www.asbmb.org. Retrieved 2017-09-22.
  12. ^ "Index of Winners - Gairdner Foundation". Gairdner Foundation. Retrieved 2017-09-22.
  13. ^ "Maquat named to receive Vanderbilt Prize in Biomedical Science". Vanderbilt University. Retrieved 2018-01-02.
  14. ^ "Maquat Receives Lifetime Achievement Award in Science from International RNA Society - ASCB". ASCB. 2017-06-14. Retrieved 2018-10-23.
  15. ^ "FASEB 2018 Excellence in Science Award Recipient Announced". FASEB. Retrieved 2017-09-22.
  16. ^ "The 17th Annual Wiley Prize in Biomedical Sciences Awarded for Elucidating the Mechanism of Nonsense-Mediated Messenger RNA Decay | Wiley News Room – Press Releases, News, Events & Media". newsroom.wiley.com. Retrieved 2018-02-26.
  17. ^ "IUBMB Jubilee Lecturers | Biochemistry and Molecular Biology, International Union". International Union of Biochemistry and Molecular Biology. Retrieved 2019-10-30.
  18. ^ Wolf Prize in Medicine 2021
  19. ^ "Lynne Maquat Wins Warren Alpert Foundation Prize".
  20. ^ "Workhorse Molecule at Center Stage". hms.harvard.edu. Retrieved 2021-05-03.
  21. ^ "2023 Gruber Genetics Prize | Gruber Foundation". gruber.yale.edu. Retrieved 2023-02-23.
  22. ^ "Johnson & Johnson Celebrates Innovation in Regulated RNA and Protein Degradation with 2024 Dr. Paul Janssen Award for Biomedical Research". JNJ.com. 2024-10-07. Retrieved 2024-10-08.
  23. ^ "2024 Recipients". Albany Med Health System. Retrieved 2024-10-10.