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M81 or M-81 may refer to:
- M-81 (Michigan highway), a state highway in Michigan
- McDonnell-Douglas MD81
- Messier 81, a spiral galaxy in the constellation Ursa Major, also known as NGC 3031 or Bode's Galaxy
- M81 Woodland, a camouflage pattern
disambiguation page lists articles associated with the same title formed as a letter-number combination.
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