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MC3T3 is an osteoblast precursor cell line derived from Mus musculus (mouse) calvaria.[1]

A number of derivatives of this strain have been isolated to select for varying degrees of osteogenic potential, and have been widely used as model systems in bone biology. A standard textbook calls its MC3T3-E1 sub-line "one of the most convenient and physiologically relevant systems for study of transcriptional control in calvarial osteoblasts." [2]


  1. ^ Kodama H. A., Amagai Y., Sudo H., Kasai S., Yamamoto S. Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn J Oral Biol. 1981. Oct;23(4):899-901.
  2. ^ Bilezikian, John P., Lawrence G. Raisz, and Gideon A. Rodan. Principles of Bone Biology. San Diego: Academic Press, 2002. p.1506

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