MED31
| Med31 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med31 | ||||||||
| Pfam | PF05669 | ||||||||
| InterPro | IPR008831 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.[1][2]It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant [3] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.[4]
References
- ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)".
- ^ Fan HY, Klein HL (August 1994). "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae". Genetics. 137 (4): 945–56. PMC 1206071. PMID 7982575.
- ^ Fan HY, Cheng KK, Klein HL (March 1996). "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae". Genetics. 142 (3): 749–59. PMC 1207016. PMID 8849885.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
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