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MVD may refer to:
- mitral valve disease, also known as mitral regurgitation or mitral insufficiency
- Marburg virus disease, a disease of humans and other primates caused by marburgviruses
- HC MVD, a Kontinental Hockey League ice hockey team, based Balashikha
- Memorial Van Damme, an annual athletics meeting in Brussels
- Mississippi Valley Division, a regional command of the U.S. Army Corps of Engineers
- Montevideo, the capital and chief port of Uruguay
- Carrasco International Airport (IATA: MVD), Uruguay's largest airport
- Motor Vehicle Division, the equivalent of the Department of Motor Vehicles in Arizona and New Mexico, United States
- Russian Ministry of Internal Affairs, Ministerstvo Vnutrennikh Del; also sometimes used to refer to the equivalent ministries in other former Soviet republics
- Most Valuable Danette, an annual award presented on The Dan Patrick Show
- multi view demo, a recording of a computer game
- multivalued dependency, in database theory, a full constraint between two sets of attributes in a relation
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