MXRA5

MXRA5
Identifiers
Aliases	MXRA5, matrix remodeling associated 5
External IDs	OMIM: 300938; HomoloGene: 56704; GeneCards: MXRA5; OMA:MXRA5 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	3,346,652 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; hair follicle; ; skin of hip; ; urethra; ; vulva; ; pylorus; ; cardia; ; parietal pleura; ; nipple; ; human penis;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function; extracellular matrix structural constituent;
Cellular component	extracellular exosome; extracellular region; collagen-containing extracellular matrix;
Biological process	response to transforming growth factor beta;
	Sources:Amigo / QuickGO
Orthologs
	25878
	n/a
	ENSG00000101825
	n/a
	Q9NR99
	n/a
	NM_015419
	n/a
	NP_056234
	n/a
	Wikidata
View/Edit Human

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.^[3]

Function

This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.^[3]

Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101825 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Matrix-remodelling associated 5". Retrieved 2012-07-24.
^ Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M (Sep 2012). "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis. 33 (9): 1797–805. doi:10.1093/carcin/bgs210. PMID 22696596.

Chondrogianni N, de C M Simoes D, Franceschi C, Gonos ES (2004). "Cloning of differentially expressed genes in skin fibroblasts from centenarians". Biogerontology. 5 (6): 401–9. doi:10.1007/s10522-004-3188-1. PMID 15609104.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (Jul 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Zou TT, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, Wang S, Olaru A, Deacu E, Liu TC, Abraham JM, Meltzer SJ (Jul 2002). "Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon". Oncogene. 21 (31): 4855–62. doi:10.1038/sj.onc.1205613. PMID 12101425.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.