Margin of exposure
In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake. It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic. This approach is preferred by both the World Health Organization and the European Food Safety Authority for the evaluation of the risk of carcinogens.
- Benford, Diane; Bolger, P. Michael; Carthew, Philip; Coulet, Myriam; DiNovi, Michael; Leblanc, Jean-Charles; Renwick, Andrew G.; Setzer, Woodrow; Schlatter, Josef; Smith, Benjamin; Slob, Wout; Williams, Gary; Wildemann, Tanja (January 2010). "Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic". Food and Chemical Toxicology. 48: S2–S24. doi:10.1016/j.fct.2009.11.003.
- "Margin of Exposure approach developed by EFSA". EFSA. Retrieved 20 November 2015.
- Lachenmeier, Dirk W.; Przybylski, Maria C.; Rehm, Jürgen (15 September 2012). "Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach". International Journal of Cancer. 131 (6): E995–E1003. doi:10.1002/ijc.27553. PMID 22447328.
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