Margin of exposure

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In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake.[1] It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic.[2] This approach is preferred by both the World Health Organization and the European Food Safety Authority for the evaluation of the risk of carcinogens.[3]


  1. ^ Benford, Diane; Bolger, P. Michael; Carthew, Philip; Coulet, Myriam; DiNovi, Michael; Leblanc, Jean-Charles; Renwick, Andrew G.; Setzer, Woodrow; Schlatter, Josef; Smith, Benjamin; Slob, Wout; Williams, Gary; Wildemann, Tanja (January 2010). "Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic". Food and Chemical Toxicology. 48: S2–S24. doi:10.1016/j.fct.2009.11.003.
  2. ^ "Margin of Exposure approach developed by EFSA". EFSA. Retrieved 20 November 2015.
  3. ^ Lachenmeier, Dirk W.; Przybylski, Maria C.; Rehm, Jürgen (15 September 2012). "Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach". International Journal of Cancer. 131 (6): E995–E1003. CiteSeerX doi:10.1002/ijc.27553. PMID 22447328.