Maria Santos may refer to:
- María Santos, Argentine actress of the 1940s
- Maria Santos (swimmer) (born 1978), Portuguese swimmer
- María Santos Corrales (1797-1881), Peruvian woman
- María Santos Gorrostieta Salazar (1976-2012), Mexican physician and politician
- Maria Santos (All My Children), a fictional character from the ABC soap opera, All My Children.
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