|Marjolin's ulcer presenting on arm following a burn|
Marjolin's ulcer refers to an aggressive ulcerating squamous cell carcinoma presenting in an area of previously traumatized, chronically inflamed, or scarred skin.:737 They are commonly present in the context of chronic wounds including burn injuries, varicose veins, venous ulcers, ulcers from osteomyelitis, and post radiotherapy scars.
Histologically, the tumour is a well-differentiated squamous cell carcinoma. This carcinoma is aggressive in nature, spreads locally and is associated with a poor prognosis. 40% occur on the lower limb and the malignant change is usually painless. This malignant change of the wound happens a long time after initial trauma, usually 10–25 years later. Its edge is everted and not always raised. More recent transcriptional analysis suggests that chronically impeded extracellular matrix turnover and epithelium-to-mesenchyme transitions in neglected scar tissue might give rise to this malignancy.
- Esther RJ, Lamps L, Schwartz HS (1999). "Marjolin ulcers: secondary carcinomas in chronic wounds". J South Orthop Assoc. 8 (3): 181–7. PMID 12132863.
- Simmons MA, Edwards JM, Nigam A (December 2000). "Marjolin's ulcer presenting in the neck". J Laryngol Otol. 114 (12): 980–2. doi:10.1258/0022215001904545. PMID 11177375.
- Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
- Phillips TJ, Salman SM, Bhawan J, Rogers GS (May 1998). "Burn scar carcinoma. Diagnosis and management". Dermatol Surg. 24 (5): 561–5. doi:10.1016/S1076-0512(98)00022-3. PMID 9598012.
- Smidt LS, Smidt LF, Chedid MB, Bavaresco CS, Chedid MF (October 2005). "Radical surgical treatment for Marjolin ulcer occurring after chronic osteomyelitis". South. Med. J. 98 (10): 1053. doi:10.1097/01.smj.0000182509.78816.7b. PMID 16295826.
- Chong AJ, Klein MB (March 2005). "Images in clinical medicine. Marjolin's ulcer". N. Engl. J. Med. 352 (10): e9. doi:10.1056/NEJMicm040020. PMID 15758002.
- Paredes F (February 1998). "[Marjölin ulcer]". Acta Med Port (in Portuguese). 11 (2): 185–7. PMID 9567417.
- Sinha S, Su S, Workentine M, Agabalyan N, Cheng M, Gabriel V, Biernaskie J (January 2017). "Transcriptional Analysis Reveals Evidence of Chronically Impeded ECM Turnover and Epithelium-to-Mesenchyme Transition in Scar Tissue Giving Rise to Marjolin's Ulcer". J Burn Care Res. 38 (1): e14–e22. doi:10.1097/BCR.0000000000000432. PMID 27679957.