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Mauzac may refer to:

  • Mauzac (grape), a grape variety mainly grown in the Limoux and Gaillac regions near Toulouse in France
  • Mauzac noir, another wine grape that is grown in Southwest France
  • Mauzac, Haute-Garonne, a commune of the Haute-Garonne département in France
  • Mauzac-et-Grand-Castang, a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France