mcrA RNA motif
 |
| mcrA | |
|---|---|
 Consensus secondary structure and sequence conservation of mcrA RNA | |
| Identifiers | |
| Symbol | mcrA |
| Rfam | RF03010 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The mcrA RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1]
mcrA motif RNAs are found in the genus Listeria, as well as two phages that infect such species: Listeria phage 2389 and Listeria phage B025.
mcrA RNAs are often found upstream of genes that encode restriction endonucleases of the mcrA type. These endonucleases are typically found in phages. This fact could suggest that the RNAs function as cis-regulatory elements. However, mcrA RNA are clearly associated with phages, which often organize their genes such that all (or many) genes are transcribed in one huge unit. Therefore, it is possible that mcrA RNAs are located upstream of protein-coding genes merely because they happen to be adjacent in these long phage transcripts.[citation needed]
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.