Megazol

Megazol
Identifiers
	IUPAC name 2-Amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole;
CAS Number	19622-55-0;
ChemSpider	27598;
CompTox Dashboard (EPA)	DTXSID50173298 ;
Chemical and physical data
Formula	C6H6N6O2S
Molar mass	226.22 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn1c(cnc1c2nnc(s2)N)[N+](=O)[O-];

Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.

A study of nitroimidazoles found the drug extremely effective against T. brucei and T. cruzi which cause Chagas disease and African sleeping sickness, respectively. The drug is considerably more effective than standard benznidazole therapy (for Chagas) which is considered the gold standard.^[1] This is despite that other nitroimidazoles proved ineffective against these pathogens.

References

^ "Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation". Antimicrob. Agents Chemother. 56 (1): 115–123. 2012. doi:10.1128/AAC.05135-11.

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[1] "Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation". Antimicrob. Agents Chemother. 56 (1): 115–123. 2012. doi:10.1128/AAC.05135-11.

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