Merafloxacin
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Formula | C19H23F2N3O3 |
Molar mass | 379.408 g·mol−1 |
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Merafloxacin is a fluoroquinolone antibacterial that inhibits the pseudoknot formation which is necessary for the frameshift in the SARS-CoV-2 genome.[1] It is a promising drug candidate for SARS-CoV-2.[2]
References
[edit]- ^ Bhatt PR, Scaiola A, Loughran G, Leibundgut M, Kratzel A, Meurs R, et al. (June 2021). "Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome". Science. 372 (6548): 1306–1313. Bibcode:2021Sci...372.1306B. doi:10.1126/science.abf3546. PMC 8168617. PMID 34029205.
- ^ Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU (October 2020). "Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro". bioRxiv. doi:10.1101/2020.10.21.349225. PMC 7587830. PMID 33106809.