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Symbol MicC
Alt. Symbols IS063
Rfam RF00121
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0000655
PDB structures PDBe

The MicC non-coding RNA (previously known as IS063 [1]) is located between the ompN and ydbK genes in E. coli. This Hfq-associated RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5' region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli.[2] The expression of micC was shown to be increased in the presence of beta-lactam antibiotics.[3]

See also[edit]


  1. ^ Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Bio Systems. 65 (2-3): 157–77. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726. 
  2. ^ Chen S, Zhang A, Blyn LB, Storz G (October 2004). "MicC, a second small-RNA regulator of Omp protein expression in Escherichia coli". Journal of Bacteriology. 186 (20): 6689–97. doi:10.1128/JB.186.20.6689-6697.2004. PMC 522180Freely accessible. PMID 15466019. 
  3. ^ Dam S, Pagès JM, Masi M (December 2017). "Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli". Antibiotics. 6 (4). doi:10.3390/antibiotics6040033. PMC 5745476Freely accessible. PMID 29211019. 

Further reading[edit]

  • Pfeiffer V, Papenfort K, Lucchini S, Hinton JC, Vogel J (August 2009). "Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation". Nature Structural & Molecular Biology. 16 (8): 840–6. doi:10.1038/nsmb.1631. PMID 19620966. 

External links[edit]