For approximately one mile beginning at MS 161 and on eastward, MS 302 is a four-lane expressway to accommodate the U.S. 61 interchange. MS 302 then continues east from U.S. 61 to U.S. 78 at Olive Branch, mainly as a four-lane highway with a center turn lane and significant commercial frontage. From U.S. 78 to MS 309, MS 302 is a four-lane expressway with at-grade intersections (with the exception of the overpass at Germantown Road/MS 305). Eastward from MS 309, the four-lane expressway continues, with a grade-separated interchange at the U.S. 72 terminus.