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Trial example now in use at Src (gene)#Additional images (pending comment):
l i p i d - b i n d i n g
P h o s p h o s e r i n e
P h o s p h o s e r i n e
SH3
S p l i c i n g v a r i a n t
SH2
V a r i a n t
P h o s p h o t y r o s i n e
h y d r o p h o b i c b i n d i n g p o c k e t
V a r i a n t
Tyrosine kinase
A c t i v e s i t e
S H 3 / S H 2 d o m a i n i n t e r f a c e
A T P
P r o t o n a c c e p t o r
a c t i v a t i o n l o o p
P h o s p h o t y r o s i n e
S - n i t r o s o c y s t e i n e
P h o s p h o t h r e o n i n e
P h o s p h o t y r o s i n e
P h o s p h o t y r o s i n e P S / P T / P S ( C D K 5 ) P h o s p h o t y r F A K 2 / a u t o s w a p p e d d i m e r / p e p t i d e b i n d a u t o i n h i b i t o r y p T y r Top row: Beta-strand region
Hydrogen bonded turn
Helical region
site
2
2
lipid-binding
site
17
17
Phosphoserine
site
35
35
Phosphoserine
site
69
69
Phosphoserine
site
74
74
Phosphothreonine
site
75
75
Phosphoserine; by CDK5
region
87
93
Beta-strand region
region
88
143
SH3
site
88
88
swapped dimer interface [polypeptide binding]
site
93
93
peptide ligand binding site [polypeptide binding]
region
99
102
Beta-strand region
region
110
114
Beta-strand region
region
117
117
Splicing variant
region
118
126
Beta-strand region
region
127
129
Hydrogen bonded turn
region
132
136
Beta-strand region
region
137
139
Helical region
region
140
142
Beta-strand region
region
146
148
Helical region
region
147
247
SH2
region
152
154
Beta-strand region
site
158
158
autoinhibitory site [polypeptide binding]
site
158
158
phosphotyrosine binding pocket [polypeptide binding]
region
158
165
Helical region
region
167
170
Beta-strand region
region
174
179
Beta-strand region
region
176
176
Variant
region
181
183
Beta-strand region
region
187
195
Beta-strand region
site
187
187
Phosphotyrosine (By similarity)
region
196
198
Hydrogen bonded turn
region
199
209
Beta-strand region
site
205
205
hydrophobic binding pocket [polypeptide binding]
region
211
213
Beta-strand region
region
215
218
Beta-strand region
region
221
225
Beta-strand region
region
226
233
Helical region
region
237
237
Variant
region
240
242
Beta-strand region
region
256
259
Beta-strand region
region
267
269
Helical region
region
270
519
Tyrosine kinase
region
270
278
Beta-strand region
site
276
276
Active site (ATP binding)
region
283
289
Beta-strand region
site
290
290
SH3/SH2 domain interface [polypeptide binding]
region
290
292
Hydrogen bonded turn
region
293
299
Beta-strand region
site
298
298
ATP
region
302
304
Hydrogen bonded turn
region
307
319
Helical region
region
328
332
Beta-strand region
region
334
336
Beta-strand region
region
338
341
Beta-strand region
region
349
353
Helical region
region
355
358
Helical region
region
363
382
Helical region
site
389
389
Proton acceptor
region
392
394
Helical region
region
395
397
Beta-strand region
region
399
401
Helical region
region
403
405
Beta-strand region
site
406
406
activation loop (A-loop)
region
410
413
Helical region
region
417
420
Helical region
site
419
419
Phosphotyrosine; by autocatalysis; alternate
site
419
419
Phosphotyrosine; by FAK2; alternate (By similarity)
region
423
426
Hydrogen bonded turn
region
429
431
Helical region
region
434
439
Helical region
site
439
439
Phosphotyrosine
region
444
459
Helical region
region
460
462
Hydrogen bonded turn
region
471
479
Helical region
region
492
501
Helical region
site
501
501
S-nitrosocysteine (By similarity)
region
506
508
Helical region
site
511
511
Phosphothreonine
region
512
520
Helical region
region
521
523
Hydrogen bonded turn
site
522
522
Phosphotyrosine
site
530
530
Phosphotyrosine; by CSK