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Monogenetic may refer to:
- Monogenetic in biology, of or pertaining to monogenesis (Mendelian inheritance)
- Monogenetic volcanic field in geology, a cluster of volcanoes that only erupted once
- Monogenetic theory of pidgins in linguistics, a theory about the origin of creole languages
- Monogenetic theory of human origins, in anthropology a theory that states humans originated in one location
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