Muisne is a coastal town in the southwest of the province of Esmeraldas in northwestern Ecuador, with 5,925 inhabitants in the last Ecuadorian census in 2010. It is the seat of the namesake canton.
It is located on the northern tip of the small semi-island known as Isla de Muisne. Also known as the enchanted island. The narrow channel between the mainland and the eastern side of the island is crossed mainly by small outboard-motorboats for passengers and by barges for cars and small trucks.
On the western side of the semi-island there is a beach which attracts both local and foreign tourists.
Within Muisne exist several parroquia's (small towns), some of which include Pedro Carlo, San Francisco del Cabo (the oldest parish), Bunche, Union of Daule, Tola, Maldonado, Bellavista, and Daule.