Multifocal fibrosclerosis

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Multifocal fibrosclerosis and idiopathic fibrosclerosis are disorders of unknown aetiology, characterised by fibrous lesions (co-)occurring at a variety of sites. Known manifestations include retroperitoneal fibrosis, mediastinal fibrosis and Riedel's thyroiditis.[1][2]

They are now considered to be manifestations of IgG4-related disease.[3]


  1. ^ Brooks, MS; Robinson, JA (1985). "Idiopathic fibrosclerosis". The Journal of rheumatology. 12 (3): 575–9. PMID 4045855. 
  2. ^ Kishimoto, M.; Okimura, Y.; Kimura, K.; Mizuno, I.; Iguchi, G.; Fumoto, M.; Takahashi, Y.; Kanda, F.; Kaji, H.; Abe, H.; Hanioka, K.; Chihara, K. (2000). "Multifocal fibrosclerosis as a possible cause of panhypopituitarism with central diabetes insipidus". Endocrine journal. 47 (3): 335–342. PMID 11036878. doi:10.1507/endocrj.47.335. 
  3. ^ John H. Stone; Arezou Khosroshahi; Vikram Deshpande; et al. (October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & Rheumatism. 64 (10): 3061–3067. PMID 22736240. doi:10.1002/art.34593.