N1-Acetyl-5-methoxykynuramine
Appearance
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Names | |
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IUPAC name
N-[3-(2-Amino-5-methoxyphenyl)-3-oxopropyl]acetamide
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3D model (JSmol)
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CompTox Dashboard (EPA)
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Properties | |
C12H16N2O3 | |
Molar mass | 236.271 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N1-Acetyl-5-methoxykynuramine (AMK) is a metabolite of melatonin that could improve memory by acting on the melatonin receptors. It significantly increased the phosphorylation of both ERK and CREB in the hippocampus.[1] It also helps scavenge free radicals.[2]
References
[edit]- ^ "Research Reveals How Melatonin Boosts Long-Term Memory". SciTechDaily. 2024-03-05. Retrieved 2024-03-11.
- ^ Ressmeyer, Anna-Rebekka; Mayo, Juan C.; Zelosko, Veronika; Sáinz, Rosa M.; Tan, Dun-Xian; Poeggeler, Burkhard; Antolín, Isaac; Zsizsik, Beata K.; Reiter, Russel J.; Hardeland, Rüdiger (2003). "Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction". Redox Report: Communications in Free Radical Research. 8 (4): 205–213. doi:10.1179/135100003225002709. ISSN 1351-0002. PMID 14599344.