NACA (gene)
Template:PBB Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.[1][2][3]
Function
NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.[2][4]
The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.[3]
Interactions
NACA has been shown to interact with BTF3, FADD,[5] C-jun,[6] and 3 members of taxilin family.[7]
References
- ^ "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide".
- ^ a b Wiedmann B, Sakai H, Davis TA, Wiedmann M (August 1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. doi:10.1038/370434a0. PMID 8047162.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Yotov WV, St-Arnaud R (February 1996). "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome. 7 (2): 163–4. doi:10.1007/BF03035343. PMID 8835540.
- ^ Rospert S, Dubaquié Y, Gautschi M (October 2002). "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. doi:10.1007/PL00012490. PMID 12475173.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Moreau A, Yotov WV, Glorieux FH, St-Arnaud R (March 1998). "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. PMC 108844. PMID 9488446.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yoshida K, Nogami S, Satoh S, Tanaka-Nakadate S, Hiraishi H, Terano A, Shirataki H (May 2005). "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells. 10 (5): 465–76. doi:10.1111/j.1365-2443.2005.00848.x. PMID 15836775.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
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