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NPD may refer to:
- National Democratic Party of Germany, a far-right political party in Germany; after its German language name, Nationaldemokratische Partei Deutschlands
- New Democratic Party of Canada, a political party in Canada, through its French language acronym NPD, standing for Nouveau Parti Démocratique
- Narcissistic personality disorder, a cluster B personality disorder
- Nitrogen–phosphorus detector, a detector used in chromatography
- Non-parental ditype, in tetrad genetic analysis
- Nuclear Power Demonstration, an early power-producing nuclear reactor in Canada
- New product development, the process of bringing a new product or service to market
- New Pudsey railway station, in England; National Rail station code NPD
- Norwegian Petroleum Directorate, Norwegian government agency
- NPD Group, a sales and market research company (formerly National Purchase Diary)
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