Negative regulatory element

A Negative regulatory element (NRE) is a sequence of DNA that represses the expression of certain genes,^[1] for example that of the insulin gene.^[2]

References

^ Hampsey, Michael. "Negative Regulatory Elements (NREs)". eLS. doi:10.1002/9780470015902.a0005030.pub2.
^ Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription

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[1] Hampsey, Michael. "Negative Regulatory Elements (NREs)". eLS. doi:10.1002/9780470015902.a0005030.pub2.

[2] Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription

[1]

[2]

v t e Regulatory sequences
General	CAAT box CCAAT box Pribnow box TATA box SECIS element A-box Z-box C-box E-box G-box
Insulin gene	A5 Z negative regulatory element C2 E2 A3 cAMP response element A2 CAAT enhancer binding (CEB) C1 E1 G1 - ILPR