Neurolysis may refer to the application of physical agents (heat or freezing) or chemicals (such as phenol, alcohol or glycerol) to a nerve to cause the temporary degeneration of the nerve's fibers in order to interrupt the transmission of nerve signals, usually for pain relief (a neurolytic block). Some authors use the term to denote just chemical neurolytic blocks, and use neurotomy to refer to neurolytic block by heat or freezing.
In peripheral nerve surgery neurolysis is the process of 'releasing the nerve from its neuroma [or mass of disconnected, regenerating nerve tissue] and surrounding scar tissue'
- Scott Fishman; Jane Ballantyne; James P. Rathmell (January 2010). Bonica's Management of Pain. Lippincott Williams & Wilkins. p. 1458. ISBN 978-0-7817-6827-6. Retrieved 15 August 2013.
- Husain, A. M. (2015). A practical approach to neurophysiologic intraoperative monitoring (2nd ed.). New York: Demos. p. 166