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Neuromedin N

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Neuromedin N[1]
Identifiers
3D model (JSmol)
  • OC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H]2CCCN2C([C@](NC([C@@H](N)CCCCN)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O
Properties
C38H63N7O8
Molar mass 745.949
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Neuromedin N
Identifiers
SymbolNN
NCBI gene4922
HGNC8038
Other data
LocusChr. 12 q21

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.[2][3][4][5][6][7]

References

  1. ^ Neuromedin N - Compound Summary, PubChem.
  2. ^ Carraway RE, Mitra SP, Spaulding G (1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 1–16. doi:10.1111/j.1749-6632.1992.tb27335.x. PMID 1463268.
  3. ^ Kitabgi P, De Nadai F, Rovère C, Bidard JN (1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 30–42. doi:10.1111/j.1749-6632.1992.tb27337.x. PMID 1463273.
  4. ^ Vincent JP (October 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037.
  5. ^ Adams DH, Hanson GR, Keefe KA (2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience. 102 (4): 843–51. doi:10.1016/S0306-4522(00)00530-3. PMID 11182247.
  6. ^ Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C (February 2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications. 290 (4): 1161–8. doi:10.1006/bbrc.2001.6308. PMID 11811984.
  7. ^ Kitabgi P (October 2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides. 27 (10): 2508–14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237.

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