Neuromedin N

Neuromedin N
Neuromedin N
Identifiers
Symbol	NN
NCBI gene	4922
HGNC	8038
Other data
Locus	Chr. 12 q21

Neuromedin N^[1]
Identifiers
CAS Number	102577-25-3 ;
3D model (JSmol)	Interactive image;
ChemSpider	8115921;
IUPHAR/BPS	1578;
PubChem CID	9940301;
CompTox Dashboard (EPA)	DTXSID20145280 ;
	InChI InChI=1S/C38H63N7O8/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53)/t23-,24-,27-,28-,29-,30-,31-,32-/m0/s1 Key: RZMLVIHXZGQADB-YLUGYNJDSA-N;
	SMILES OC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H]2CCCN2C([C@](NC([C@@H](N)CCCCN)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O;
Properties
Chemical formula	C38H63N7O8
Molar mass	745.949
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.^[2]^[3]^[4]^[5]^[6]^[7]

References

^ Neuromedin N - Compound Summary, PubChem.
^ Carraway RE, Mitra SP, Spaulding G (1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 1–16. doi:10.1111/j.1749-6632.1992.tb27335.x. PMID 1463268.
^ Kitabgi P, De Nadai F, Rovère C, Bidard JN (1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 30–42. doi:10.1111/j.1749-6632.1992.tb27337.x. PMID 1463273.
^ Vincent JP (October 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037.
^ Adams DH, Hanson GR, Keefe KA (2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience. 102 (4): 843–51. doi:10.1016/S0306-4522(00)00530-3. PMID 11182247.
^ Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C (February 2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications. 290 (4): 1161–8. doi:10.1006/bbrc.2001.6308. PMID 11811984.
^ Kitabgi P (October 2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides. 27 (10): 2508–14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237.

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[1] Neuromedin N - Compound Summary, PubChem.

[pmid1463268-2] Carraway RE, Mitra SP, Spaulding G (1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 1–16. doi:10.1111/j.1749-6632.1992.tb27335.x. PMID 1463268.

[pmid1463273-3] Kitabgi P, De Nadai F, Rovère C, Bidard JN (1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 30–42. doi:10.1111/j.1749-6632.1992.tb27337.x. PMID 1463273.

[pmid8719037-4] Vincent JP (October 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037.

[pmid11182247-5] Adams DH, Hanson GR, Keefe KA (2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience. 102 (4): 843–51. doi:10.1016/S0306-4522(00)00530-3. PMID 11182247.

[pmid11811984-6] Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C (February 2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications. 290 (4): 1161–8. doi:10.1006/bbrc.2001.6308. PMID 11811984.

[pmid16904237-7] Kitabgi P (October 2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides. 27 (10): 2508–14. doi:10.1016/j.peptides.2006.03.038. PMID 16904237.

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