OGC may refer to:
- OGC, Open Geospatial Consortium, a standards organization for geospatial information systems
- OGC Nice French association football club based in Nice
- Oculogyric crisis, a dystonic reaction to certain drugs and/or medical conditions
- Office of Government Commerce, a department of the government of the United Kingdom
- Office of the General Counsel, in many corporations and public institutions
- O.G.C. (band), Originoo Gunn Clappaz, a hip hop group from Brooklyn, New York
- Oregon Graduate Center, a private college in suburban Portland, Oregon
- Outwood Grange College, a large British secondary school and sixth form in Wakefield, West Yorkshire
- OGC Osservatorio Giuseppe Conzo Giuseppe Conzo's Observatory, Italy
- Organically Grown Company (Oregon), an organic produce wholesale company
- Orchestral Game Music Concerts, a series concerts of video game music performed in Tokyo, Japan
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