OMB may stand for:
- Office of Management and Budget, US
- Olympiade Mathématique Belge (Belgian Mathematical Olympiad), a mathematical competition
- OMB, a graphic design studio founded by Oscar Mariné Brandi
- Ontario Municipal Board, Canada
- Oregon Marching Band, of the University of Oregon
- Oregon Medical Board
- omb, ISO code for the East Ambae language of Vanuatu
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