Omero is an Italian given name whose English equivalent is Homer.
Omero may refer to:
- OMERO, a research data management platform for biology image files.
- Omero Antonutti (born 1935), Italian actor and dubber
- Omero Bonoli (1909–1934), Italian gymnast and 1932 Olympic pommel horse silver medalist
- Omero Carmellini (born 1921), Italian retired footballer
- Omero Losi (born 1925), Italian retired footballer
- Omero Tognon (1924–1990), Italian footballer
- Omeros, an epic poem by Nobel Prize-winning author Derek Walcott
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