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Omphalocele

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Omphalocele
SpecialtyMedical genetics Edit this on Wikidata

An omphalocele (British English: omphalocoele) is a rare abdominal wall defect in which the intestines, liver, and occasionally other organs remain outside of the abdomen in a sac because of a defect in the development of the muscles of the abdominal wall (exomphalos). Omphalocele occurs in 1/4,000 births and is associated with a high rate of mortality (25%) and severe malformations, such as cardiac anomalies (50%) and neural tube defect (40%). Approximately 15% of live-born infants with omphalocele have chromosomal abnormalities. About 30% of infants with an omphalocele have other congentital abnormalities.[1]

Signs and symptoms

The sac, which is formed from an outpouching of peritoneum, protrudes in the midline, through the umbilicus (navel).

It is normal for the intestines to protrude from the abdomen, into the umbilical cord, until about the tenth week of pregnancy, after which they return to inside the fetal abdomen.

The omphalocele can be mild, with only a small loop of intestines present outside the abdomen, or severe, containing most of the abdominal organs. In severe cases surgical treatment is made more difficult because the infant's abdomen is abnormally small, having had no need to expand to accommodate the developing organs.

Larger omphalocele are associated with a higher risk of cardiac defects.[2]

Screening

An omphalocele is often detected through AFP screening or a detailed fetal ultrasound. Genetic counseling and genetic testing such as amniocentesis are usually offered during the pregnancy.

Causes

Caused by malrotation of the bowels while returning to the abdomen during development. Some cases of omphalocele are believed to be due to an underlying genetic disorder, such as Edward's syndrome (Trisomy 18)[3][4] or Patau Syndrome (Trisomy 13).

Beckwith-Wiedemann syndrome is also associated with omphaloceles.

Gastroschisis is a similar birth defect, but in gastroschisis the umbilical cord is not involved and the lesion is usually to the right of midline. Parts of organs may be free in the amniotic fluid, and not enclosed in a membranous (peritoneal) sac. Gastroschisis is less frequently associated with other defects than omphalocele.

Omphaloceles occurs more frequently with increased maternal age.[5]

Other related syndromes are Pentalogy of Cantrell, Beckwith-Wiedemann, and OEIS complex (omphalocele, exstrophy of the cloaca, imperforate anus, spinal defects).

International Omphalocele Awareness Day

International Omphalocele Awareness Day is celebrated annually on January 31, as part of Birth Defect Awareness Month. The first "O" Awareness Day was in 2012. Participants wear black and white, the color of the MOOs - Mothers of Omphaloceles, in an effort to raise awareness and support for omphalocele, and many share facts and information through e-mail, Facebook, Twitter, and Blogs.

In the United States, Arkansas, California, Georgia, Michigan, and Nebraska have passed resolutions to officially recognize January 31 as International Omphalocele Awareness Day.[6][7][8][9][10]

Support

MOO - Mothers of Omphaloceles - The Mothers of Omphaloceles is support group for parents, grandparents, and families of children born with omphalocele, as well as individuals born with omphalocele themselves. They can be found both through Yahoo Groups and on Facebook.


GEEPS - Gastroschisis Exomphalos Extrophies Parent Support - GEEPS is a support group for parents of children born with either Gastroschisis or Exomphalos.

Celebrities

Christina Milian's sister Danielle's new born baby son was born with an omphalocele, and died on August 27, 2015.[11]

Rev Run from rap group Run-D.M.C had a daughter, Victoria Anne Simmons, who died from the condition. This was documented on the MTV reality show Run's House.

References

  1. ^ Fifth Edition: Diseases of the Human Body: Page 124: Author: Tamparo&Lewis
  2. ^ "Impact of omphalocele size on associated conditions". Journal of Pediatric Surgery. 43: 2216–2219. doi:10.1016/j.jpedsurg.2008.08.050.
  3. ^ Kanagawa SL, Begleiter ML, Ostlie DJ, Holcomb G, Drake W, Butler MG (2002). "Omphalocele in three generations with autosomal dominant transmission". J. Med. Genet. 39 (3): 184–5. doi:10.1136/jmg.39.3.184. PMC 1735073. PMID 11897819.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Yatsenko SA, Mendoza-Londono R, Belmont JW, Shaffer LG (2003). "Omphalocele in trisomy 3q: further delineation of phenotype". Clin. Genet. 64 (5): 404–13. doi:10.1034/j.1399-0004.2003.00159.x. PMID 14616763.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Tamparo, Carl (2011). Fifth Edition : Diseases of the Human Body. Philadelphia, PA: F.A Davis Company. pg. 124. ISBN 978-0-8036-2505-1
  6. ^ http://www.arkleg.state.ar.us/assembly/2015/2015R/Bills/HR1006.pdf, House Resolution 1006, State of Arkansas
  7. ^ https://legiscan.com/CA/text/SR56/2015, California Senate Resolution 56
  8. ^ http://www.legis.ga.gov/Legislation/en-US/display/20152016/HR/1171, Georgia House Resolution
  9. ^ http://www.legislature.mi.gov/%28S%28h332eyphewi4vrrkhozpaomq%29%29/mileg.aspx?page=getObject&objectName=2016-HR-0209, Michigan House Resolution 0209
  10. ^ http://www.nebraskalegislature.gov/FloorDocs/104/PDF/Intro/LR21.pdf, Nebraska Legislative Resolution 21
  11. ^ Quad. "Christina Milian Dead Nephew: Danielle's Born With Abdominal Organs Outside The Body Because Of Navel Opening". jobsnhire.com. Retrieved 30 August 2015.
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